https://www.selleckchem.com/products/pdd00017273.html Periprosthetic joint infection (PJI) is a devastating complication following total knee arthroplasty (TKA). Two-stage revision has traditionally been considered the gold standard of treatment for established infection, but increasing evidence is emerging in support of one-stage exchange for selected patients. The objective of this study was to determine the outcomes of single-stage revision TKA for PJI, with mid-term follow-up. A total of 84 patients, with a mean age of 68 years (36 to 92), underwent single-stage revision TKA for confirmed PJI at a single institution between 2006 and 2016. In all, 37 patients (44%) were treated for an infected primary TKA, while the majority presented with infected revisions 31 had undergone one previous revision (36.9%) and 16 had multiple prior revisions (19.1%). Contraindications to single-stage exchange included systemic sepsis, extensive bone or soft-tissue loss, extensor mechanism failure, or if primary wound closure was unlikely to be achievable. Patients were not clusion criteria. Cite this article 2021;2(5)305-313. One-stage exchange, using a strict debridement protocol and multidisciplinary input, is an effective treatment option for the infected TKA. This is the largest single-surgeon series of consecutive cases reported to date, with broad inclusion criteria. Cite this article Bone Jt Open 2021;2(5)305-313.A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.Background On the Internet, individuals can freely read about or talk to others about suicide. However, little is known about the nature of these online interactions and the potential impact on users. Aims This study aimed to examine the characteristics of online comments following high-profile celebrity suicide, comparing top-rated comments with controversial comments. Method Comments from a popular thread on Reddit made followin