The results have been obtained are of an intermediate nature, which propose to continue and complete this research by studying the entire Georgian PKU population.We have studied efficiency of hyaluronidase ointment created on the base of microbial hyaluronidase preparation "Bilidase" in treatment of postoperative hypertrophic scars. A total number of 14 patients with postoperative hypertrophic scars on different part of face were enrolled in the study. All patients were treated with hyaluronidase ointment by help of iontophoresis for 10 days -1 procedure per day and than retreated 1 time with the same regimen at 4-week interval. Scar conditions were assessed in terms of pigmentation, vascularity, pliability, height, pain and pruritis in accordance with the Vancouver Scar Scale (VSS). The data of this investigation indicate that treatment of postoperative scars with hyaluronidase ointment significantly improves the function as well as a cosmetic appearance of scar tissues. Each of the investigated parameters was improved significantly after hyaluronidase treatment. Total score after 1 cycle of treatment was 5.14±0.9 vs 10±1.5 before treatment and after 2 cycles of treatment. total score was 0.85±0.9 vs 10±1.5 before treatment (p less then 0.001). Hyaluronidase ointment could also be recommended for preventing the scar formation in plastic surgery.The treatment of posterior pelvic ring fracture with the early mobilization purpose is surgery, which traditionally uses screws and sacral bar. We have created a new trans-iliac dynamic nail (TIDN) for fixation of the posterior pelvic ring. The advantage of TIDN is minimally invasion due to combination of interlocking nailing with the possibility of compression and decompression. Exam the biomechanical properties of a new trans-iliac dynamic nail (TIDN). The current biomechanical study investigated dynamic tensile and compression tests; static torsional, compression, tensile tests. The study yielded equivalent results for the static torsional test and in dynamic tests, but found the TIDN superior in the static compression test and static tensile test in comparison with other researchers. Based upon the results of this biomechanical study, we conclude that the TIDN proved to be an effective device for posterior pelvic ring injury fixation. The clinical trial should be next.The idea to use living microorganisms for disease prevention and treatment was introduced a century ago, but yet the full potential and benefits of microbial therapeutics has not been entirely understood. In the light of developments of human microbiome studies, probiotics are gaining new momentum, where health benefit conferring by Lactobacillus are emerging as one of the novel approaches in the treatment and prophylactics of dysbiosis.  https://www.selleckchem.com/products/gyy4137.html  The present review focuses on the origin and development of the probiotic's concept, mechanisms of action and anticipated use of probiotic Lactobacillus as well as of microbial therapeutics. The required regulatory frameworks associated with probiotic use and marketing are discussed.This study was devoted to the investigation of antioxidant homeostasis in spleen tissue of white rats in the dynamics of development of colon adenocarcinoma induced by the introduction of sym-dimethylhydrazine (DMH). The effectiveness of the antioxidant barrier (Cu,Zn-superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, reduced glutathione) and oxidative damage products (TBARS, advanced oxidation protein products, diene and triene conjugates, Schiff bases) were measured in the homogenate of spleen tissue. A violation of the redox balance due to the accumulation of lipid peroxidation products, a decrease in the activity of antioxidant enzymes and antioxidant mediators of non-enzymatic nature was established. The development of oxidative stress leads to disruption of the synthesis of glutathione peroxidase and glutathione reductase in the endoplasmic reticulum, i.e., to inhibition of the functional activity of the glutathione-dependent unit of the antioxidant system. DMH-induced carcinogenesis is associated with enzymatic/non-enzymatic redox imbalance as well as increased oxidative damage to proteins and lipids. Evaluation of redox biomarkers can be potential diagnostic indicator of colon adenocarcinoma advancement.Chronic lymphocytic leukemia (CLL) is the most common adult leukaemia in the US and in Europe, including Georgia. CLL presents with clonal expansion and accumulation of CD5+CD19+CD23+ cells in peripheral lymphoid organs and tissues and in bone marrow. The disease remains incurable, albeit there are new molecular and immunotherapy methods currently available, which, in conjunction with chemotherapy, lead to the "precision therapy" approach. The majority of immunotherapies are based on the ability of therapeutic antibodies to mobilize anti-tumour potential of immune responses. Bispecific antibodies (BsAb) are also considered in the treatment of CLL, whereby phagocytic cells play a key effector role in the destruction of the target CLL cells. Anti-CD19/anti-CD64 BsAb binds to CD19 receptors on CLL cells and to CD64 receptors (FcγRI) on monocytes and activated polymorphonuclear neutrophils (PMNs), thus inducing phagocytosis of the leukaemic cells. The aim of this study was to evaluate the ability of anti-CD19/CD64 BsAb on enhancing attachment of leukaemic cells to PMNs in CLL patients is limited and its application should be based on the assessment of individual capacity of the patients' phagocytic cells.The aim of the work is to compare the effect on the strength of bone tissue of spraying ceramic materials on the surface of titanium-nickel plates and pins and to show the results of electron microscopic examination of bone micropreparations at the site of immersion of the implant. Preparations of rat tibia after metal osteosynthesis with intramedullary titanium-nickel pins and titanium-nickel bone plates with spraying on their surface material based on bioactive glass, hydroxyapatite and pins and plates without spraying were investigated. Using a device based on a strain gauge and a caliper with digital display recorded load-deformation diagrams during compression of the test sample, as well as perform bone sampling at the site of immersion of the implant and determine morphological changes in bone using an electron microscope. The greatest strength was observed when using a titanium-nickel pin sprayed with biocomposite, titanium-nickel plate sprayed with biocomposite, hydroxyapatite doped with silver (8 weeks after surgery).