https://www.selleckchem.com/products/smoothened-agonist-sag-hcl.html 3%] plasmapheresis) resulting in 1219 CCP units. Production of CCP increased as processes were automated and streamlined, from a mean of 11 donors collected/day for the first month to a mean of 25 donors collected/day in the subsequent 2 weeks. Backlogged orders were cleared, and inventory began to accumulate 4 weeks after project initiation. The BC was able to implement an effective de novo CCP collection program within 6 weeks in response to a community need in a global pandemic. Documentation of the experience may inform preparedness for future pandemics. The BC was able to implement an effective de novo CCP collection program within 6 weeks in response to a community need in a global pandemic. Documentation of the experience may inform preparedness for future pandemics.The Infrared (IR) and Raman spectra of various interstitial carbon defects in silicon are computed at the quantum mechanical level by using an all electron Gaussian type basis set, the hybrid B3LYP functional and the supercell approach, as implemented in the CRYSTAL code (Dovesi et al. J. Chem. Phys. 2020, 152, 204111). The list includes two 〈100〉 split interstitial IXY defects, namely ICC and ICSi , a couple of related defects that we indicate as IX IY , the so called C i C s 0 in its A and B form, as well as SiCi Si and Cs Ci Cs , in which the interstitial carbon atom is twofold coordinated. The second undergoes a large relaxation, and the final configuration is close to ICC Cs . Geometries, relative stabilities, electronic, and vibrational properties are analysed. All these defects show characteristic features in their IR spectrum (above 730 cm-1 ), whereas the Raman spectrum is dominated, in most of the cases, by the pristine silicon peak at 530 cm-1 , that hides the defect peaks. Due to isotope fractionations during partial nitrogen release from minerals and rocks, the complete extraction of nitrogen for analysis is crucial