https://www.selleckchem.com/products/bmh-21.html Repulsive osmotic delamination is thermodynamically allowed "dissolution" of two-dimensional (2D) materials and therefore represents an attractive alternative to liquid-phase exfoliation to obtain strictly monolayered nanosheets with an appreciable aspect ratio with quantitative yield. However, osmotic delamination was so far restricted to aqueous media, severely limiting the range of accessible 2D materials. Alkali-metal intercalation compounds of MoS2 or graphite are excluded because they cannot tolerate even traces of water. We now succeeded in extending osmotic delamination to polar and aprotic organic solvents. Upon complexation of interlayer cations of synthetic hectorite clay by crown ethers, either 15-crown-5 or 18-crown-6, steric pressure is exerted, which helps in reaching the threshold separation required to trigger osmotic delamination based on translational entropy. This way, complete delamination in water-free solvents like aprotic ethylene and propylene carbonate, N-methylformamide, N-methylacetamide, and glycerol carbonate was achieved.Pure silk fibroin (SF) hydrogel exhibits poor elasticity and low water retention ability, owing to the compact crystalline structure and high content of hydrophobic amino acids. Herein, a composite double-network hydrogel of SF and tyramine-modified hyaluronic acid (mHA) was constructed, via the laccase-catalyzed coupling reactions between the phenolic hydroxyl groups from SF and mHA chains. The obtained hydrogel exhibits improved structural stability and flexibility compared to pure SF hydrogel. Meanwhile, the swelling ratio, mechanical property, drug loading, and release behaviors can be readily regulated by alcoholization, altering pH value, and ionic strength of soaking solutions. Increasing pH values promoted the swelling capacity of SF/mHA hydrogel, resulting in an efficient loading of cationic drugs and sustained release of anionic drugs as well. The addition of i