BACKGROUND Minimally invasive surgery (MIS) for evacuation of spontaneous intracerebral hemorrhage (ICH) has shown promise but there remains a need for intraoperative performance assessment considering the wide range of evacuation effectiveness. In this feasibility study, we analyzed the benefit of intraoperative 3-dimensional imaging during navigated endoscopy-assisted ICH evacuation by mechanical clot fragmentation and aspiration. METHODS 18 patients with superficial or deep supratentorial ICH underwent MIS for clot evacuation followed by intraoperative computerized tomography (iCT) or cone-beam CT (CBCT) imaging. Eligibility for MIS required (a) availability of intraoperative iCT or CBCT, (b) spontaneous lobar or deep ICH without vascular pathology, (c) a stable ICH volume (20-90 ml), (d) a reduced level of consciousness (GCS 5-14), and (e) a premorbid mRS ≤ 1. Demographic, clinical, and radiographic patient data were analyzed by two independent observers. RESULTS Nine female and 9 male patients with a median age of 76 years (42-85) presented with an ICH score of 3 (1-4), GCS of 10 (5-14) and ICH volume of 54 ± 26 ml. Clot fragmentation and aspiration was feasible in all cases and intraoperative imaging determined an overall evacuation rate of 80 ± 19% (residual hematoma volume 13 ± 17 ml; p  less then  0.0001 vs. Pre-OP). Based on the intraoperative imaging results, 1/3rd of all patients underwent an immediate re-aspiration attempt. No patient experienced hemorrhagic complications or required conversion to open craniotomy. However, routine postoperative CT imaging revealed early hematoma re-expansion with an adjusted evacuation rate of 59 ± 30% (residual hematoma volume 26 ± 37 ml; p  less then  0.001 vs. Pre-OP). CONCLUSIONS Routine utilization of iCT or CBCT imaging in MIS for ICH permits direct surgical performance assessment and the chance for immediate re-aspiration, which may optimize targeting of an ideal residual hematoma volume and reduce secondary revision rates.Herpes viruses have been described as markers of occult cancer and have also been implicated in oncogenesis. This group of viruses includes varicella-zoster virus (VZV) which is well-known for its ability to evade the immune response by lying dormant in the dorsal root ganglion of peripheral nerves. Although it is common knowledge that VZV reactivation causes herpes zoster (shingles), there have been no reports in literature of herpes zoster manifesting in the dermatomal territory of peripheral nerves involved by either benign or malignant tumors. We report two cases of patients with peripheral nerve tumors who presented with herpes zoster in the dermatomal distribution of the involved nerves. One patient had primary neurolymphomatosis, whereas the other had a sacral schwannoma. We believe these are the first cases to be reported that demonstrate herpes zoster at clinical presentation in patients with peripheral nerve tumors. This suggests that VZV may have the potential to cause peripheral nerve tumors via a complex interplay of viral oncogenes and alterations in host immunological responses.BACKGROUND The role of point-of-care ultrasonography (POCUS) is rapidly expanding in both resource-rich and resource-limited settings (RLS). One limitation to this rapid expansion has been the lack of educators adequately trained to teach this user-dependent skill. This is particularly true in RLS, where disease presentations, infrastructure limitations, and approach to medical education present unique challenges to the direct application of resource-rich emergency department POCUS curricula. OBJECTIVES We describe the point-of-care ultrasound in resource-limited settings (PURLS) fellowship, a novel curriculum designed to provide advanced training and expertise in clinical care and POCUS application and education in RLS. CONCLUSION Our curriculum design is one approach to create context-specific POCUS education for use in RLS, thereby improving patient care.PURPOSE The incidence of oropharyngeal squamous cell carcinoma continues to rise with the majority of patients receiving definitive or adjunctive radiation. For patients with locoregional recurrence after radiation, optimal treatment involves salvage surgery. The aim of this study is to identify factors that predict survival to ultimately improve patient selection for salvage surgery. METHODS Retrospective cohort study at an NCI-designated cancer center. We analyzed patients with a history of head and neck radiation who presented with persistent/recurrent or second primary disease requiring salvage oropharyngeal resection from 1998-2017 (n = 120). Patients were stratified into three classes based on time to recurrence and presence of laryngopharyngeal dysfunction.  https://www.selleckchem.com/products/mivebresib-abbv-075.html  Primary outcomes were 5-year overall survival (OS) and disease specific survival (DSS). RESULTS Median OS was 27 months (median follow-up 20 months). Five-year OS was 47% for class I (recurrence > 2 years), 26% for class II (recurrence ≤ 2 years), and 0% for class III (recurrence ≤ 2 years and laryngopharyngeal dysfunction), (p  less then  0.0001). Five-year DSS showed significant differences between classes (p  less then  0.0001). On multivariate analysis, class remained predictive of OS (p = 0.04-  less then  0.001) and DSS (p = 0.04-0.001). Adjuvant radiation after salvage surgery with negative margins showed superior OS (71% vs. 28%, p = 0.01) and DSS (83% vs 37%, p = 0.02) compared to surgery alone and was a significant predictor of improved survival on multivariate analysis (HR 0.1, p = 0.04). CONCLUSION This study identified a subset of patients with oropharyngeal cancer recurrence within two years of initial treatment and with laryngopharyngeal dysfunction who have poor outcomes for salvage surgery.PURPOSE Previous studies have shown that inflammatory markers are associated with hearing impairment in participants with inflammatory diseases. Therefore, screening for inflammatory status may have value in predicting the risk of hearing loss (HL) in participants with underlying inflammation. Therefore, red cell distribution width (RDW), an indirect indicator of inflammatory status, was used. The aim of the present study was to evaluate the clinical association between RDW and hearing impairment in a Korean population with chronic kidney disease (CKD). METHODS In this cross sectional study, a total of 461 participants with estimated glomerular filtration rate (eGFR)  40 dB. RESULTS The numbers of participants in the Low, Middle, and High tertiles were 172, 154, and 135, respectively. The AUROCs of RDW and hs-CRP for HL were 0.644 and 0.522, respectively. In the multivariate analysis, the Low/Mid-Freq, High-Freq, and AHT values were lowest in the participants in the Low tertile compared with those in the Middle or High tertiles Multivariate logistic regression analyses showed that participants in the High tertile exhibited 2.