f lung involvement was significantly associated with Galectin-3 levels (p less then 0.01 r 0.76). Stepwise logistic regression model showed that the levels of ferritin (odds ratio [OR] = 0.05, p0.08) and Galectin-3 (OR = 0.1, p less then 0.01) were significantly and independently associated with typical pneumonia in COVID-19 patients. When COVID-19 patients were evaluated in terms of typical pneumonia, we determined a cut-off value of 18,9 ng/ml for Galectin-3 via ROC analysis. (87% sensitivity; 73% specificity; Area Under Curve (AUC) 0.89; p less then 0.001) Conclusion Galectin-3 was found as a diagnostic tool for COVID-19 associated typical pneumonia and as an indicator of both pneumonia and its severity.Background/aim Increased length of stay (LOS) in the palliative care unit (PCU) is a serious burden to the patients and the health care system. The predictors of longer LOS in a PCU have not been reported so far from Turkey. Our aim in this study was to evaluate the factors associated with the LOS in the PCU of a tertiary hospital. Materials and methods This cross-sectional analysis of a retrospective cohort evaluated adult patients' medical records admitted to the PCU between 2017 and 2019. The main inclusion criteria were four or more days of palliative unit stay and being home discharge during the study period. Data on demographics, chronic diseases, mobilization disability, route of feeding, tracheostomy, sleep disturbances, pressure ulcers, and antidepressant use were collected. Potential factors associated with prolonged LOS tertiles were examined by ordinal regression analysis.  https://www.selleckchem.com/products/jsh-150.html  Results A total of 287 discharges from the PCU to home were analyzed. Mean (SD) age was 70.5 (15.8) years, and there was a mal LOS in the PCU in patients discharged home.
  miRNAs control various biological functions such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGF-1 gene were determined by in silico estimation.
 
  The study included 30 healthy controls (HC) and 20 patients with acromegaly. Anterior pituitary functions and disease activities of patients with acromegaly were evaluated at the time of study. The miR-29c-3p, miR-31-5p and miR-18a-5p levels were measured using quantitative Real-Time PCR (RT-qPCR).
 
  The expression level of miR-29c-3p was significantly lower in patients with acromegaly compared to the HC group (p<0.001). This downregulation was more pronounced in patients with inadequately controlled acromegaly than in patients with acromegaly controlled with SSA therapy (p=0.016). Univariate logistic regression analysis results showed that down regulation of miR-29c-3p expression increases the risk of developing acromegaly [OR (95% Cl)=1.605 (1.142-2.257), p=0.006]. There was no significant difference between the groups in terms of miR-31-5p and miR-18a-5p expression levels (p=0.375 and p=0.649, respectively).
 
  Plasma miR-29c-3p expression level is downregulated in patients with acromegaly, and this is more pronounced in patients with inadequate control.
 Plasma miR-29c-3p expression level is downregulated in patients with acromegaly, and this is more pronounced in patients with inadequate control.The historical analysis and the results of research activities of the Department of Forensic Medicine of the Sechenov University on the study of blood stains as important material evidence in forensic medicine and forensic science are presented. The personal contribution to the solution of this problem of outstanding forensic doctors whose life and work was associated with the department was noted.The review of the world literature on the most common causes, mechanism of development and diagnostic signs of sudden autopsy-negative cardiac death is presented. Two groups of reasons for the development of this pathology were identified - traumatic and non-traumatic. The traumatic group includes the cardio-inhibitory reflex and the trigemino-cardiac reflex. The non-traumatic group included prolonged Q-T interval syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia. The importance of postmortem molecular genetic research in cases of sudden cardiac death in order to prevent the deaths in the victim's relatives is noted. The criteria for the diagnosis of reflex cardiac arrest are indicated.In the forensic practice of examining bone remains there are cases of anomalies' detection of the skeleton development which have a high identification value for the search for a missing person. The most valuable ones are the features of the facial skull anatomical structure since they are usually well visible and recorded in photographic and medical documents. In the presented case an anomaly in the hard palate development was revealed on the skull of an unknown person found in the Leningrad region - a cleft caused by its underdevelopment.A case of COVID-19-associated acute hemorrhagic necrotizing encephalopathy in adults in combination with comorbid pathology was analyzed. The key data of the medical history, the results of laboratory and instrumental studies are presented. The results of postmortem forensic medical diagnostics with demonstration and description of macro- and microscopic changes in the examined organs are presented.The data on the use of mathematical modeling of spleen injury by the method of fine element analysis within the framework of a forensic medical examination of a spleen injury with the circumstances of causing injury to the victim deliberately established by the investigating authority. The result of the conducted mathematical modeling showed the adequacy of the created model and accurate reproduction of the results in spleen injury which makes it promising to introduce this method into daily expert practice.