https://www.selleckchem.com/products/gdc-0068.html These regional differences are more pronounced under a best-case climate scenario (RCP2.6), illustrating that strong climate change (RCP8.5) may override any regional buffer capacities. The main variables determining extinction risks differed between the two continental regions, with annual temperature range and cropland expansion being important in EAS, and annual precipitation being important in ENA. These results suggest that disparities in regional exposure to anthropogenic environmental changes may cause congeneric species with relatively similar sensitivity to have different future risks of extinction. Moreover, the findings highlight the context-specific nature of anthropogenic effects on biodiversity and the importance of making region-specific policies for conservation and restoration in response to the intensifying global changes. According to an influential taxonomy of varieties of uncertainty in health care, existential uncertainty is a key aspect of uncertainty for patients. Although the term "existential uncertainty" appears across a number of disciplines in the research literature, its use is diffuse and inconsistent. To date there has not been a systematic attempt to define it. The aim of this study is to generate a theoretically-informed conceptualisation of existential uncertainty within the context of an established taxonomy. Existential uncertainty was subjected to a concept analysis, which drew on existing uses of the term across multiple disciplines as well as insights from uncertainty theory more broadly and from the existential therapy literature to generate a tentative definition of the concept. Antecedents, consequences, and empirical referents of existential uncertainty were also identified. A model case was described as well as a borderline case and a related case in order to illustrate and delineate the concept. r being-in-the-world, and these can be challenged by a serious diagnosis. It