https://www.selleckchem.com/products/ab680.html Wastewater reclamation and reuse is a sustainable solution for alleviating the scarcity of water resources. However, the potential risks resulting from the residual pollutants in reclaimed water are of concern. Identifying of priority pollutants would be a practical approach for the management and scientific evaluation of risks associated with reclaimed water reuse. In this study, a novel risk score-based method is proposed for prioritizing residual pollutants in reclaimed water. First, target the specific applications and possible scenarios of reclaimed water as well as recognize the potential receptors and exposure pathways. Second, determine exposure and effect parameters, and assign values to every parameter. Third, calculate the total exposure score and effect score for each pollutant using a weighted method, then calculate the risk score by multiplying total exposure score and effect score, and rank all pollutants based on their risk scores from high to low. Fourth, recommend a priority pollutants list for reclaimed water reuse. To demonstrate the procedure and validate the method, a case study on groundwater recharge with reclaimed water was conducted. In the case study, EE2 and E2, which have also been listed in other recent water quality standards, were identified as priority pollutants. The case study illustrated sufficient reliability, great discrimination and feasibility of the method. The five exposure parameters and seven effect parameters in this method can objectively evaluate the potential risk of pollutants and identify priority pollutants for the specific application of reclaimed water. This application-oriented and risk-based prioritization method is easy to understand and simple to operate in practice. This study fills existing gaps by proffering a novel prioritization method to identify priority pollutants in reclaimed water for an accurate evaluation and safety management of recycled wastewater.C