hone, and 92% were interested in receiving health-related information via a mobile phone. Among those who were interested in receiving information via a mobile phone, 84% preferred voice calls, and 7% and 1% preferred texting and apps, respectively. CONCLUSIONS Results from this study indicate that a digital health intervention that leverages feature-phones combined with female community health volunteers may be an acceptable and pragmatic way to implement an evidence-based program to reduce hypertension in rural Nepal. ©Zhao Ni, Namratha Atluri, Ryan J Shaw, Jingru Tan, Kinza Khan, Helena Merk, Yunfan Ge, Shrinkhala Shrestha, Abha Shrestha, Lavanya Vasudevan, Biraj Karmacharya, Lijing L Yan. Originally published in JMIR mHealth and uHealth (http//mhealth.jmir.org), 09.03.2020.BACKGROUND In the past several years, gamified learning has been growing in popularity in various medical educational contexts including cardiopulmonary resuscitation (CPR) training. Furthermore, prior work in Basic Life Support (BLS) training has demonstrated the benefits of serious games as a method for pretraining among medical students. However, there is little evidence to support these benefits with regard to Advanced Life Support (ALS) training. OBJECTIVE We compare the effects of a brief precourse ALS preparation using a serious smartphone game on student knowledge, skills, and perceptions in this area with those of conventional ALS training alone. METHODS A serious game (Resus Days) was developed by a Thai physician based on global ALS clinical practice guidelines. Fifth-year medical students were enrolled and randomized to either the game group or the control group. Participants in both groups attended a traditional ALS lecture, but the game group was assigned to play Resus Days for 1 hour before atttraining course resulted in better algorithm knowledge scores for medical students than attending the course alone. TRIAL REGISTRATION Thai Clinical Trials Registry HE611533; https//tinyurl.com/wmbp3q7. ©Pariwat Phungoen, Songwoot Promto, Sivit Chanthawatthanarak, Sawitree Maneepong, Korakot Apiratwarakul, Praew Kotruchin, Thapanawong Mitsungnern. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 09.03.2020.BACKGROUND Obesity surgery has proven its effectiveness in weight loss. However, after a loss phase of about 12 to 18 months, between 20% and 40% of patients regain weight. Prediction of weight evolution is therefore useful for early detection of weight regain. OBJECTIVE This proof-of-concept study aimed to analyze the postoperative weight trajectories and to identify "curve families" for early prediction of weight regain. METHODS This was a monocentric retrospective study with calculation of the weight trajectory of patients having undergone gastric bypass surgery. Data on 795 patients after a 2-year follow-up allowed modeling of weight trajectories according to a hierarchical cluster analysis (HCA) tending to minimize the intragroup distance according to Ward. Clinical judgement was used to finalize the identification of clinically relevant representative trajectories.  https://www.selleckchem.com/products/sb297006.html  This modeling was validated on a group of 381 patients for whom the observed weight at 18 months was compared to the predicted weight. RESULmeglio, Guillaume Becouarn, Philippe Topart, Rodolphe Bodin, Jean Christophe Buisson, Patrick Ritz. Originally published in JMIR Medical Informatics (http//medinform.jmir.org), 09.03.2020.AIMS The novel sirolimus-eluting ultra-high molecular weight 115-microns strut thickness APTITUDE® Bioreabsorbable vascular scaffold (BRS) (Amaranth Medical Inc., Mountain View, CA) displays higher mechanical strength, expansion capabilities and resistance to fracture compared to clinically available BRS technologies. RENASCENT II is a prospective, multi-center first-in-human clinical study to evaluate the clinical performance of the APTITUDE® BRS in the treatment of single de novo coronary lesions among patients undergoing percutaneous coronary intervention. METHODS AND RESULTS APTITUDE® BRS was tested in a prospective study in two countries (Italy and Colombia). Study objectives were angiographic in-scaffold late lumen loss (IS-LLL) measured by quantitative coronary angiography (QCA) and target vessel failure (TVF) defined as the composite rate of cardiac death, target vessel myocardial infarction (TV-MI) or ischemia driven target lesion revascularization (TLR) at 9-and 24-months. A total of 60 patients were enrolled. All patients underwent lesion pre-dilatation and 46 patients (76.7%) underwent post-dilatation. Clinical device and procedural success were 98.3% (59/60 patients) and 100% respectively. Angiographic late lumen loss was 0.19 ± 0.26mm at 9-months and 0.3 ± 0.41mm at 24-months. At 9-months, TVF occurred in 2/59 (3.4%) due to TV-MI but no TLR. No further cases of TVF, MACE or stent thrombosis were reported upto 24-months follow-up. CONCLUSIONS In this multi-center prospective study, the APTITUDE® BRS was shown to be safe and effective in the treatment of single coronary lesions at 24-months clinical follow up.AIMS This study sought to compare thromboresistance and albumin binding capacity of different durable polymer DESs using dedicated preclinical and in vitro models. METHODS AND RESULTS In an ex vivo swine arterio-venous shunt model, fluoropolymer everolimus-eluting stent (FP-EES) (n=14) was compared with two durable polymer DES (BioLinx polymer coated zotarolimus-eluting stent (BL-ZES)(n=9) and a CarboSil® elastomer polymer coated ridaforolimus-eluting stent (EP-RES)(n=6)), and bare metal stents (BMS)(n=10). Stents underwent immunostaining using a cocktail of anti-platelet antibodies and a marker for inflammation and then were evaluated by confocal microscopy (CM). Albumin retention was assessed by using a flow loop model with labeled human serum albumin [FP-EES(n=8), BL-ZES(n=4), EP-RES(n=4), and BMS(n=7)] and scanned by CM. The area of platelet adherence (normalized to total stent surface area) was lower in order of FP-EES (9.8%), BL-ZES (32.7%), EP-RES (87.6%) and BMS (202.0%) and inflammatory cell densities was least for FP-EES less then BL-ZES less then EP-RES less then BMS.