https://www.selleckchem.com/products/VX-702.html Affective disorders promote poorer outcomes in hemodialysis patients. According to the presence or not of depression/anxiety in these patients, aims were to analyze differences in sociodemographic, clinical and/or psychological factors and to identify predictors. One hundred eighty-six hemodialysis patients were classified based on their depression/anxiety status. Basal characteristics showed differences between groups where mainly male sex (Depression OR 0.2; Anxiety OR 0.3) albumin (Depression OR 0.1; Anxiety OR 0.2) and calcium levels (Depression OR 0.5; Anxiety OR 0.4), impaired quality of life (Depression OR 1.4; Anxiety OR 1.2) and psychological inflexibility (Depression OR 1.3; Anxiety OR 1.2) were associated (all p less then 0.01) to these mental conditions. Multivariate models showed that worse quality of life (OR 1.3; p less then 0.001) predicted depression while marital status (with a partner; OR 0.3; p = 0.025) and albumin levels (OR 0.1; p = 0.027) were protective factors. Depression represented a risk factor for anxiety (OR 1.2; p = 0.001), although calcium levels (OR 0.5; p = 0.039) would protect this state. Interestingly, psychological inflexibility predicted both disorders (Depression OR 1.2, p less then 0.001 and Anxiety OR 1.1; p = 0.002). Results highlight the relevance of well-trained multidisciplinary hemodialysis units to control the influence of these factors on the presence of depression/anxiety, and thus, their impact on the patients' outcomes.Metabolic reactions that occur at alkylamino moieties may provide insight into the roles of these moieties when they are parts of drug molecules that act at different receptors. N-dealkylation of N,N-dialkylamino moieties has been associated with retaining, attenuation or loss of pharmacologic activities of metabolites compared to their parent drugs. Further, N-dealkylation has resulted in clinically used drugs, activation of prodrugs, change of recepto