https://www.selleckchem.com/products/apr-246-prima-1met.html Moreover, within-person cross-lagged analysis revealed that changes in repetitive negative thinking both predicted and were predicted by changes in perceived stress. No such within-person reciprocal relations were found for positive reappraisal. This study covered only a period of five months, used self-report measures, and was conducted in a community sample. Furthermore, 25% of the participants did not complete all 20 waves of data collection. These findings help to understand the enduring trait-like processes and within-person factors that may contribute to the longitudinal course of habitual repetitive negative thinking and positive reappraisal. These findings help to understand the enduring trait-like processes and within-person factors that may contribute to the longitudinal course of habitual repetitive negative thinking and positive reappraisal.Biomimetic materials are often capable of subtly affecting tissue development, regeneration and carcinogenesis due to their high similarity to natural tissues. Despite the benefit of using such materials in tissue engineering, their prospective use in cancer therapy has been neglected, particularly the functions and mechanisms by which biomimetic materials mediate tumor suppression. Here, we prepare hierarchically constructed bone-mimetic selenium-doped hydroxyapatite nanoparticles (B-SeHANs), which recapitulate the uniaxially oriented hierarchical structure of bone HA and can potentially play a dual role in the postoperative treatment of bone tumors via the chemotherapy from selenium and the promotion of bone repair by hydroxyapatite, to systematically investigate the influence of bone-mimetic hierarchical structure in bone tumor inhibition by SeHANs in vivo and in vitro. We found that, compared to the non-biomimetic SeHANs, the B-SeHANs exhibited highly enhanced cellular internalization and intracellular degradation, and induced subsequent autophagy and ca