Today, personalized medicine is essentially based on individual "omics." However there is a need to integrate this approach with a number of data such as pharmacokinetics, optimal dose and duration of drug treatments, age and gender differences, and drug interactions, which are relevant in terms of benefits and risks but are frequently unknown. This requires independent research that should be supported by governments in order to make personalized medicine a reality.On 1 March 2020, the amendments to the German Protection Against Infection Act that were introduced by the act to protect against measles and strengthen vaccination prevention (Measles Protection Act) entered into force. The reason for the changes is that the number of individuals with measles has significantly increased in recent years. To protect public health, the Measles Protection Act has implemented regulations requiring that persons in certain institutions must either have adequate protection against measles or have immunity to measles.  https://www.selleckchem.com/products/Beta-Sitosterol.html  In this article the current legal situation with regard to health care facilities is presented.Activities undertaken by householders in their gardens have huge potential to enhance city-wide biodiversity, but programs aimed at activating householders require an understanding of the factors encouraging or acting as barriers to the uptake of different kinds of activities. We provided 42 householders with two species-enhancing activities, selected from six possibilities, free-of-charge (to remove the barrier of initial cost). We collected socio-demographic data as well as information on knowledge of common urban species, pro-environmental behaviors and nature connectedness. We monitored ongoing engagement at two time points 1 and 6 months. Characteristics of householders opting for different activities varied in terms of their degree of environmental engagement, their knowledge about common species, and the size of their gardens; e.g., bird feeders and bee planters were popular with people who did not know the names of common species and were not particularly engaged in pro-environmental activities respectively, whereas lizard habitat creation was attractive to people who were already engaged in wildlife gardening activities. Cost to continue with activities was a significant barrier for some people, but most householders were willing to practice relatively inexpensive activities in small spaces. Esthetics was an important factor to be considered when enhancing invertebrate habitat (e.g., bug hotels are more attractive than log piles, and planters for bees contain colorful flowers). A commonly cited barrier was lack of information about wildlife-friendly activities, despite much being available online. Most participants (85%) talked about their activities with others, potentially acting as influencers and shifting social norms.OBJECTIVE To assess whether there are differences in musculoskeletal pain among different types of occupations offshore and their relationship to ergonomic demands. METHODS We conducted a web-based cross-sectional survey among workers from offshore wind energy companies operating within the German exclusive economic zone. We selected workers with regular offshore commitments and at least 28 days spent offshore in the past year (n = 268). Musculoskeletal pain was assessed using the Subjective Health Complaints inventory (SHC), which considers the past month. RESULTS Of the 268 male participants eligible for analysis, 54% reported back pain 50.4% neck pain, 40.3% lower back pain, 35.5% shoulder, 23.3% arm and 22.1% leg pain, all of them during the past month. Compared to other offshore occupations, technicians reported more frequently arm (OR 3.13; 95% CI 1.58-6.19), back (OR 1.97; 95% CI 1.15-3.39), shoulder (OR 1.94; 95% CI 1.11-3.40) and neck pain (OR 1.89; 95% CI 1.11-3.22). After adjusting for age and nationality, lifting and carrying heavy loads were associated with all types of pain except leg pain. Overhead work, work in awkward postures, and the use of personal protection equipment and heavy tools was associated with shoulder, back and arm pain. CONCLUSIONS Our findings suggest that occupational health counselling, health promotion and preventive interventions of offshore wind energy workers needs to consider the specific tasks of the employee and be particularly tailored to the ergonomic needs of technicians.BACKGROUND Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional outcome. METHODS A multi-centre, prospective cohort study of CSDH patients was performed between May 2013 and January 2014. Patients aged > 16 years undergoing burr hole evacuation of primary CSDH with pre- and postoperative imaging were included in this subgroup analysis. Baseline and clinical details were collected. Pre- and postoperative maximal subdural width and midline shift (MLS) along with clot density were recorded. Primary outcomes comprised mRS at discharge and symptomatic recurrence requiring re-drainage. Comparisons were made using multiple logistic regression. RESULTS Three hundred nineteen patients were identified for inclusion. Two hundred seventy-two of 319 (85%) patients underwent drain insertion at the time of surgery versus 45/319 (14%) who did not. Twenty-nine of 272 patients who underwent drain insertion experienced recurrence (10.9%) versus 9 of 45 patients without drain insertion (20.5%; p = 0.07). Overall change in median subdural width was significantly greater in the drain versus 'no drain' groups (11 mm versus 6 mm, p  less then  0.01). Overall change in median midline shift (MLS) was also significantly greater in the drain group (4 mm versus 3 mm, p  less then  0.01). On multivariate analysis, change in maximal width and MLS were significant predictors of recurrence, although only the former remained a significant predictor for functional outcome. CONCLUSIONS The use of subdural drains results in significantly improved postoperative imaging in burr hole evacuation of CSDH, thus providing radiological corroboration for their recommended use.