Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.Aerogel fibers with ultrahigh porosity and ultralow density are promising candidates for personal thermal management to reduce the energy waste of heating an entire room, and play important roles in reducing energy waste in general. However, aerogel fibers generally suffer from poor mechanical properties and complicated preparation processes. Herein, we demonstrate hierarchically porous and continuous silk fibroin/graphene oxide aerogel fibers (SF/GO) with high strength, excellent radiative heating performance, and thermal insulation performance through coaxial wet spinning and freeze-drying. The hollow CA/PAA fibers prepared via a coaxial wet spinning process have multiscale porous structures, which are not only beneficial for the formation of an SF/GO aerogel core, but also help to improve the mechanical strength of the aerogel fibers. Moreover, the prepared aerogel fibers show comparable porosity and mechanical properties with those of hollow CA/PAA fibers. More importantly, GO can dramatically improve the infrared radiative heating properties, and the surface temperature is increased by 2.6 °C after exposure to infrared radiation for 30 s, greatly higher than that of hollow fiber and SF aerogel fibers. Furthermore, the integration of hierarchically porous hollow fibers and SF/GO aerogels prevents thermal convection, decreases thermal conduction, and suppresses thermal radiation, rendering the SF/GO aerogel fiber with excellent thermal insulation performance. This work may shed light on the heat transfer mechanism of the microenvironment between the human body and textiles and pave the way for the fabrication of high-performance aerogel fibers used for personal thermal management.The metabotropic glutamate receptor subtype mGluR5 has been proposed as a potential drug target for CNS disorders such as anxiety, depression, Parkinson's disease, and epilepsy.  https://www.selleckchem.com/products/l-glutamic-acid-monosodium-salt.html  The AstraZeneca compound AZD9272 has previously been labeled with carbon-11 and used as a PET radioligand for mGluR5 receptor binding. The molecular structure of AZD9272 allows one to label the molecule with fluorine-18 without altering the structure. The aim of this study was to develop a fluorine-18 analogue of AZD9272 and to examine its binding distribution in the nonhuman primate brain in vivo as well as to obtain whole body radiation dosimetry. 18F-AZD9272 was successfully synthesized from a nitro precursor. The radioligand was stable, with a radiochemical purity of >99% at 2 h after formulation in a sterile phosphate buffered solution (pH = 7.4). After injection of 18F-AZD9272 in two cynomolgus monkeys, the maximum whole brain radioactivity concentration was 4.9-6.7% of the injected dose (n = 2) and PET images showed a pattern of regional radioactivity consistent with that previously obtained for 11C-AZD9272. The percentage of parent radioligand in plasma was 59 and 64% (n = 2) at 120 min after injection of 18F-AZD9272, consistent with high metabolic stability. Two whole body PET scans were performed in nonhuman primates for a total of 231 min after injection of 18F-AZD9272. Highest uptakes were seen in liver and small intestine, followed by brain and kidney. The estimated effective dose was around 0.017 mSv/MBq. 18F-AZD9272 shows suitable properties as a PET radioligand for in vivo imaging of binding in the primate brain. 18F-labeled AZD9272 offers advantages over 11C-AZD9272 in terms of higher image resolution, combined with a longer half-life. Moreover, based on the distribution and the estimated radiation burden, imaging of 18F-AZD9272 could be used as an improved tool for quantitative assessment and characterization of AZD9272 binding sites in the human brain by using PET.The structure and ultrafast photodynamics of ∼8 nm Au@Pt core-shell nanocrystals with ultrathin ( less then 3 atomic layers) Pt-Au alloy shells are investigated to show that they meet the design principles for efficient bimetallic plasmonic photocatalysis. Photoelectron spectra recorded at two different photon energies are used to determine the radial concentration profile of the Pt-Au shell and the electron density near the Fermi energy, which play a key role in plasmon damping and electronic and thermal conductivity. Transient absorption measurements track the flow of energy from the plasmonic core to the electronic manifold of the Pt shell and back to the lattice of the core in the form of heat. We show that strong coupling to the high density of Pt(d) electrons at the Fermi level leads to accelerated dephasing of the Au plasmon on the femtosecond time scale, electron-electron energy transfer from Au(sp) core electrons to Pt(d) shell electrons on the sub-picosecond time scale, and enhanced thermal resistance on the 50 ps time scale. Electron-electron scattering efficiently funnels hot carriers into the ultrathin catalytically active shell at the nanocrystal surface, making them available to drive chemical reactions before losing energy to the lattice via electron-phonon scattering on the 2 ps time scale. The combination of strong broadband light absorption, enhanced electromagnetic fields at the catalytic metal sites, and efficient delivery of hot carriers to the catalyst surface makes core-shell nanocrystals with plasmonic metal cores and ultrathin catalytic metal shells promising nanostructures for the realization of high-efficiency plasmonic catalysts.Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human primary alveolar epithelial cells, fibroblasts, and endothelial cells, with or without macrophages for predicting long-term responses to aerosols. Following thorough characterization of the model, proinflammatory and profibrotic responses based on the adverse outcome pathway concept for lung fibrosis were assessed upon repeated subchronic exposures (up to 21 days) to two types of multiwalled carbon nanotubes (MWCNTs) and silica quartz particles. We simulate occupational exposure doses for the MWCNTs (1-30 μg/cm2) using an air-liquid interface exposure device (VITROCELL Cloud) with repeated exposures over 3 weeks. Specific key events leading to lung fibrosis, such as barrier integrity and release of proinflammatory and profibrotic markers, show the responsiveness of the model.