Evidence from the published literature suggests that DEBs are safe in preventing peripheral ISR. Despite strong corporate pressure for the use of DEBs, there is only circumstantial evidence that this is a useful modality for ISR. Results from on-going studies may allow further meta-analysis for efficiency and cost-effectiveness.
 Evidence from the published literature suggests that DEBs are safe in preventing peripheral ISR. Despite strong corporate pressure for the use of DEBs, there is only circumstantial evidence that this is a useful modality for ISR. Results from on-going studies may allow further meta-analysis for efficiency and cost-effectiveness.
  This clinical trial aims to evaluate the outcome (up to 24-months) of the treatment of in-stent restenotic or reoccluded lesions in the femoropopliteal arteries, by comparing the treatment of the GORE<sup>®</sup> VIABAHN<sup>®</sup> Endoprosthesis with PROPATEN Bioactive Surface (W. L. Gore & Associates, Flagstaff, AZ, USA) with a standard PTA treatment. The primary effectiveness endpoint of the study is the primary patency at 12 months, defined as no evidence of restenosis or occlusion within the originally treated lesion based on color-flow duplex ultrasound (PSVR≤2.5) and without target lesion revascularization (TLR) within 12 months. The primary safety endpoint is the proportion of subjects who experience serious device-related adverse events within 30 days postprocedure.
 
  A total of 83 patients meeting inclusion and exclusion criteria have been enrolled in this prospective, randomized, multicenter, controlled study in 7 sites between June 2010 and February 2012. Patients wi4 and 5). In the PTA group, 36 (81.8%) patients were claudicants (Rutherford 2 and 3) and 8 (18.2%) presented with critical limb ischemia (Rutherford 4 and 5). The 12-month primary patency rates were 74.8% for the VIABAHN<sup>®</sup> group and 28.0% for the PTA group (P<0.001). No patients were reported to have device-related serious adverse events within 30 days postprocedure. The primary patency rate for the 24-month follow-up was 58.40% in the Viabahn group and 11.60% in the PTA group (P<0.001).
 
  The treatment of femoropopliteal in-stent restenosis with a VIABAHN<sup>®</sup> Endoprosthesis shows significantly better results than the treatment with a standard PTA balloon. This demonstrates that the use of the VIABAHN<sup>®</sup> Endoprosthesis is a very promising tool for the treatment of complex in-stent restenosis.
  Endoprosthesis is a very promising tool for the treatment of complex in-stent restenosis.Native Hawaiian and other Pacific Islanders, and the environment they are in relationship with, have been the targets of exploitation, extraction, and destruction. Environmental atrocities throughout the Pacific have demonstrated how imperialism, capitalism, and white supremacy drive destruction through efforts to dominate and exploit for material gain. The relationship between Pacific people and the environment, which defines who they are socially, spiritually, and ancestrally, continues to be damaged and even severed by these injustices. The purpose of this article is to provide examples of major environmental injustices in the Pacific and to develop a deeper understanding of the relationship between settler colonialism and environmental injustices. Indigenous knowledge, with a focus on traditional ecological knowledge, is incorporated not just to demonstrate the deep impact of injustices on Pacific people's cultures but also to highlight how this way of knowing cultivates a path to revitalization and community resilience. Cultural practices rooted in traditional ecological knowledge, such as the preservation of food systems, promote reciprocity between living beings and self-determination, necessary for community flourishing. With this understanding, Pacific peoples' relationship with their land offers further evidence of the critical role culture and Indigenous knowledge can play in environmental justice policies and practices.Climate change and human activities continue to result in negative environmental impacts that alter land productivity, ecosystem health, and their potential land uses. However, these environmental impacts are being addressed through land restoration frameworks that do not include the robust narrative on the links between land and Indigenous peoples. This link between land and Indigenous peoples is not visible in restoration frameworks owing to the linearity of these frameworks and their deep roots in Western science. In this article, the authors contend that restoration projects must incorporate indicators that reevaluate restoration through an Indigenous lens.  https://www.selleckchem.com/products/filgotinib.html  Through a literature review and their ongoing restoration project, they identify three major indicators that are important to incorporate in restoration ecocolonialism, kincentric ecology, and environmental narratives. They apply these indicators to provide the historical context of their ongoing field site, Daybreak Star Indian Cultural Center located at Discovery Park, the largest urban park in Seattle, Washington. They conclude that incorporating these three indicators into restoration frameworks not only indigenizes restoration but also can help create more effective solutions to environmental problems persisting for decades in unhealthy ecosystems.For over 50 years, the people of the Amskapi Piikani (Blackfeet) Nation have relayed information of "something bad" being covertly dumped within their remaining homelands. These stories, addressing contaminated waste and the locations of rumored dump sites, have also been linked with perceived cancer clusters among residents who live within the Blackfeet Nation. The concept of environmental injustice suggests that often the most vulnerable populations, including communities of color, experience the most negative realities of environmental toxic exposures, and it is not uncommon for toxic wastes to be disposed of within Native American lands. Given that Blackfeet communities suffer from some of the highest rates of cancer in the state of Montana, these narratives warrant further investigation. This research examined whether illicit dumping within Blackfeet sovereign lands can be substantiated and if this is a case of environmental injustice. This investigation employed a mix of both traditional Indigenous and Western-based scientific methodologies, both quantitative and qualitative.