https://www.selleckchem.com/products/blebbistatin.html The DS was assessed by Kruskal-Wallis and Dunn's tests. The color was evaluated by ANOVA and Tukey's HSD. There was no significant difference in the degree of bleaching among the groups. DS was significantly more accentuated in the 48-hour period. The DS was significantly higher for the PL group and significantly lower for the PO group. The desensitizing agents reduced the DS without affecting the effectiveness of the bleaching treatment. Both desensitizing agents provided greater control over pain compared to the placebo group. Potassium oxalate showed greater pain control than potassium nitrate. Both desensitizing agents tested did not interfere in the degree of whitening. Both desensitizing agents provided greater control over pain compared to the placebo group. Potassium oxalate showed greater pain control than potassium nitrate. Both desensitizing agents tested did not interfere in the degree of whitening. To compare the effects of whitening toothpaste and bleaching with 6% hydrogen peroxide (H2O2) on discoloration of dental resin composite caused by cigarette smoke (CS) and electronic vapor product (EVP) aerosol. 40 resin composite discs were divided into three groups 15 each for CS and EVP aerosol exposure and 10 for air exposure (control). Exposures were performed for 15 days, with daily brushing with regular toothpaste. Two whitening sessions, including 21 days of brushing with whitening toothpaste and 3 days of treatments with take-home bleaching (6% H2O2), were performed after the exposure. Color and gloss were assessed before exposure, at every 5 days of exposure, and after each whitening session. After 15 days of exposure, marked discoloration of resin composite was observed in the CS group (ΔE = 23.66 ± 2.31), minimal color change in the EVP group ((ΔE = 2.77 ± 0.75), and no color change in the control group. Resin composites exposed to CS did not recover their original color after treatment withle