https://www.selleckchem.com/products/r-gne-140.html Present analysis is relevant to set a reference for pathophysiological studies and to define specific targets for the test of therapeutic interventions in this widely used AD transgenic model. Microneedling as an adjuvant to topical medications has shown promising but variable results in the treatment of melasma. To conduct a systematic review and meta-analysis on the efficacy of microneedling as an adjuvant to topical therapies for the treatment of melasma. This study followed PRISMA guidelines. All comparative, prospective studies on the use of topical interventions with microneedling for the treatment of melasma were included. Studies involving radiofrequency microneedling were excluded. Twelve eligible studies comprising 459 patients from 7 different countries were included. Topical therapies included topical tranexamic acid, vitamin C, platelet-rich plasma, non-hydroquinone-based depigmentation serums, and hydroquinone-based depigmenting agents. Topical therapy with microneedling improved melasma severity with a large effect (standardized mean difference >0.8) beyond 8weeks, with best results seen at 12weeks. Compared to topical therapy alone, topical therapy with microneedling resulted in an additional improvement in melasma severity with a moderate effect at 8weeks and a large effect at 12-16weeks. Microneedling was well tolerated across studies, with no serious adverse events reported. Heterogeneity in study designs did not allow for a comparison of the efficacy of various topical therapies with microneedling. Microneedling is useful adjuvant to topical therapies for the treatment of melasma. Microneedling is useful adjuvant to topical therapies for the treatment of melasma.Antibiotics are extensively used for growth promotion purposes in intensive aquaculture. In Chile, the use of antibiotics in salmon farming is excessive, approximately 62 times more than is used in Norway. In the salmon industry, antibio