https://www.selleckchem.com/products/fps-zm1.html In this study, Vanin-1 was shown to play an important role in the treatment of cancer, and the study of Vanin-1 may provide an idea for the treatment of cancer in the future.Monitoring hypoxia-related changes in subcellular organelles would provide deeper insights into hypoxia-related metabolic pathways, further helping us to recognize various diseases on subcellular level. However, there is still a lack of real-time, in situ, and controllable means for biosensing in subcellular organelles under hypoxic conditions. Herein, we report a reductase and light programmatical gated nanodevice via integrating light-responsive DNA probes into a hypoxia-responsive metal-organic framework for spatiotemporally controlled imaging of biomolecules in subcellular organelles under hypoxic conditions. A small-molecule-decorated strategy was applied to endow the nanodevice with the ability to target subcellular organelles. Dynamic changes of mitochondrial adenosine triphosphate under hypoxic conditions were chosen as a model physiological process. The assay was validated in living cells and tumor tissue slices obtained from mice models. Due to the highly integrated, easily accessible, and available for living cells and tissues, we envision that the concept and methodology can be further extended to monitor biomolecules in other subcellular organelles under hypoxic conditions with a spatiotemporal controllable approach.The self-supporting graphdiyne/exfoliated graphene (GDY/EG) composites materials were prepared by the solvothermal method and applied as lithium-ion batteries (LIBs). Graphdiyne (GDY) is a new type of carbon allotrope with a natural macroporous structure, but its conductivity is poor. A small amount of highly conductive graphene can improve surface conductivity and facilitate electron transport. The layered GDY/graphene heterogeneous interface can reduce the electron aggregation polarization, enhance the ability to obtain