Nickel selenide nanomaterials (NiSe2 NMs) with different vacancies demonstrated high catalytic activity as electrocatalyst in oxygen evolution reaction. As the growing needs of the industrial applications in electrocatalyst, the increased occupational exposure and environmental releasing of NMs would be unavoidable. While, much efforts have been made to evaluate the ecological safety of such engineered NMs at unrealistically high concentrations, failed to provide the comprehensively guideline for exposure thresholds. To supplement the current knowledge gap, we testified the cytotoxicity of NiSe2/rGO nanocomposites with different surface defects under more realistic exposure mode. Compared with the short-term exposure and repetitive exposure, rat lung macrophages exhibited the augmented oxidative stress, dysfunction of mitochondria, damage of DNA and disorder of calcium homeostasis under the long-term NiSe2/rGO exposure. Noteworthily, no significant differences could be found between the NiSe2/rGO with different surface defects, indicated that the defect type of NMs were not the accurate predictor for real risk assessment. Collectively, the study provided the real potential toxic effects and exposure thresholds of NMs that might be highly possible industrial produced, and appealed the new insight for risk assessments of engineered NMs under the long-term exposure, which exhibited difference from the traditional evaluation of short-term and repetitive exposure.
  Social rhythmicity refers to the regularity with which one engages in social and lifestyle activities. Social rhythms have important implications for health and well-being including the prevention and treatment of mental health disorders. Existing research on social rhythmicity has focused on the link with bipolar disorder and, to a lesser extent, with depression. However, it is unclear how social rhythms are tied to anxiety disorders or what might mediate this association. Sleep shows potential as an underlying link, particularly sleep behaviors and sleep thoughts.
 
  The current study used a sample of 3,284 adults to examine the role of sleep thoughts and behaviors as mediators of the association between social rhythms and mental health symptoms of depression and anxiety.
 
  Parallel mediation models revealed that greater social rhythmicity is directly associated with fewer depressive and anxiety symptoms, and that healthier sleep behaviors and thoughts mediate this association.
 
  This study used cross-sectional data and was limited in racial and ethnic diversity.
 
  The findings highlight the critical role lifestyle regularity plays in depressive and anxious symptom pathology in a large sample of adults across the lifespan. Results also highlight the complementary roles for both sleep behaviors and thoughts by demonstrating their concurrent links between regularity and mental health. Future work is needed to further disentangle the association of these constructs with mental health.
 The findings highlight the critical role lifestyle regularity plays in depressive and anxious symptom pathology in a large sample of adults across the lifespan. Results also highlight the complementary roles for both sleep behaviors and thoughts by demonstrating their concurrent links between regularity and mental health. Future work is needed to further disentangle the association of these constructs with mental health.
  Older population with depression symptoms reached about 64 million in China. Under the World Health Organization's (WHO) age-friendly communities framework, this study explored relationships between neighbourhood environment characteristics and depressive symptoms among community-dwelling older adults in China.
 
  Data were obtained from the China Family Panel Studies (CFPS), a national multi-stage probability sample in China. The final analytic sample comprised 5,641 older adults in China. Neighbourhood environment characteristics were measured in three ways objective facilities, interviewers' evaluation, and respondents' own perceptions on the neighbourhood environment. Depressive symptoms were measured by the 20-item version of the Center for Epidemiologic Studies Depression Scale (CES-D).  https://www.selleckchem.com/products/ipi-549.html  Multilevel regression models were applied.
 
  Neighbourhoods with more exercise and recreational facilities, better interviewers' evaluations, and better objective respondents' perceptions on neighbourhood environment atand mental health among older adults, to promote ageing in place in China. Great importance should be attached to the improvement of both physical and social aspects of the neighbourhoods to develop age-friendly communities.In this study, a method that will aid in the visualization of vein topology on a target area on the body of a human subject is demonstrated. An external cooling means is configured to cool the left forearm of fourteen study participants, effecting an active thermal change or recovery in the target area upon removal of cooling. An infrared (IR) thermal camera was used to capture a series of transient thermal images. These images were then processed to extract Dynamic synthetic images (SI) throughout the active thermal change or recovery process. Dynamic SI was calculated using a quantitative parameter called tissue activity ratio (TAR), which is defined by the rate of rewarming to the rate of cooling at each pixel of interest. A fixed step size of rewarming temperature (0.5 °C) was used to progressively extract multiple synthetic images throughout the whole recovery process. Compared to a Static SI extraction method, where only a single SI results from the whole active dynamic thermography (ADT) sequence, this study demonstrates a live feed of high contrast vein visualizations by using the Dynamic SI method. Furthermore, the dependency of Dynamic SI contrast on the temperature of the external cooling stimulation was investigated. Three cooling stimulation temperatures (5 °C, 8 °C, and 11 °C) were tested, where no statistically significant difference in the resulting SI contrast was found. Lastly, a discussion is put forth on assisting venipuncture or cannulation-based clinical applications, through the incorporation of the proposed method with a projection system.