Three-dimensional graphene (3D-Gr) with excellent light absorption properties has received enormous interest, but in conventional processes to prepare 3D-Gr, amorphous carbon layers are inevitably introduced as buffer layers that may degrade the performance of graphene-based devices. Herein, 3D-Gr is prepared on germanium (Ge) using two-dimensional graphene (2D-Gr) as the buffer layer. 2D-Gr as the buffer layer facilitates the in situ synthesis of 3D-Gr on Ge by plasma-enhanced chemical vapor deposition (PECVD) by promoting 2D-Gr nucleation and reducing the barrier height. The growth mechanism is investigated and described. The enhanced light absorption as confirmed by theoretical calculation and 3D-Gr/2D-Gr/Ge with a Schottky junction improves the performance of optoelectronic devices without requiring pre- and post-transfer processes. The photodetector constructed with 3D-Gr/2D-Gr/Ge shows an excellent responsivity of 1.7 A W-1 and detectivity 3.42 × 1014 cm Hz1/2 W-1 at a wavelength of 1550 nm. This novel hybrid structure that incorporates 3D- and 2D-Gr into Ge-based integrated circuits and photodetectors delivers excellent performance and has large commercial potential.Sponges based on short electrospun fibers have received significant attention due to their ultra-high porosity, lightweight, and multifunctional characteristics. In particular, polyimide (PI) sponges have been researched due to their exceptional mechanical properties and thermal stability. Nevertheless, a number of sponges, including PI, are usually hydrophobic and synthesised in toxic, non-water solvents (e.g. 1,4-dioxane). Conversely, hydrophilic sponges disintegrate upon contact with water. Here, we suggest a new strategy to fabricate PI sponges in water by introducing a suitable surfactant, sodium dodecylbenzenesulfonate (SDBS) (sPI sponges). With less than 1 wt% of SDBS with respect to PI short fibers, they can be homogenously dispersed in water and mixed well with poly(amic acid) (PAA) solution. The synthesized sponge, depending on the concentration of SDBS, showed hydrophilic properties and substantial water uptake above 5000%. The hydrophilic properties of the sponges, which are not common, and the preparation from aqueous solution introduce new research opportunities. Such hydrophilic sponges are particularly special because they do not swell in contact with water, which makes them dimensionally stable. The methods presented here can serve as a milestone for the future development of various kinds of hydrophilic sponges applied for various applications, ranging from tissue engineering to oil/water separation.The identification of proteins that bind selectively to nucleic acid sequences is an ongoing challenge. We previously synthesized nucleobase amino acids designed to replace proteinogenic amino acids; these were incorporated into proteins to bind specific nucleic acids predictably. An early example involved selective cell free binding of the hnRNP LL RRM1 domain to its i-motif DNA target via Watson-Crick-like H-bonding interactions. In this study, we employ the X-ray crystal structure of transcriptional regulator Rob bound to its micF promoter, which occurred without DNA distortion. Rob proteins modified in vivo with nucleobase amino acids at position 40 exhibited altered DNA promoter binding, as predicted on the basis of their Watson-Crick-like H-bonding interactions with promoter DNA A-box residue Gua-6. Rob protein expression ultimately controls phenotypic changes, including resistance to antibiotics. Although Rob proteins with nucleobase amino acids were expressed in Escherichia coli at levels estimated to be only a fraction of that of the wild-type Rob protein, those modified proteins that bound to the micF promoter more avidly than the wild type in vitro also produced greater resistance to macrolide antibiotics roxithromycin and clarithromycin in vivo, as well as the β-lactam antibiotic ampicillin. Also demonstrated is the statistical significance of altered DNA binding and antibiotic resistance for key Rob analogues. These preliminary findings suggest the ultimate utility of nucleobase amino acids in altering and controlling preferred nucleic acid target sequences by proteins, for probing molecular interactions critical to protein function, and for enhancing phenotypic changes in vivo by regulatory protein analogues.Currently, four-dimensional (4D) printing programming methods are mainly structure-based, which usually requires more than one material to endow products with site-specific attributes. Here, we propose a new 4D printing programming approach that enables site-specific shape-morphing behaviors in a single material by regulating the printing parameters. Specifically, a direct ink writing three-dimensional (3D) printer with the ability to change printing parameters (e.g., deposition speed) on the fly is reported. By site-specifically adjusting print speed and print path to control the local nematic arrangements of printed liquid crystal elastomers (LCEs), the shape-morphing behaviors of the LCEs can be successfully programmed. In this way, locally programmed popping-up, self-assembling, and oscillating behaviors can be designed by varying the print speed in specific regions. Snake-like curling is realized by uniformly boosting the print speed in a single line. Furthermore, two theories and an ultrasound image diagnostic apparatus are employed to reveal the mechanism behind this behavior. This work provides a feasible way to realize the gradient transition of material properties through a single material. It broadens the design space and pushes the envelope of 4D printing, which is expected to be helpful in the fabrication of soft robotics and flexible electronics.Background Since December 2019, the outbreak of the novel coronavirus has impacted nearly >90,000 people in more than 75 countries.  https://www.selleckchem.com/products/ki16198.html  In this case report, we aim to define the chest computed tomography findings of 2019-novel coronavirus associated with pneumonia and its successful resolution after treatment. Case Report A fifty-year-old female patient, who is a businesswoman, presented with chief complaints of “fever for one week, diarrhea, anorexia, and asthenia.” Initially, she was given Tamiflu. The influenza A virus serology was negative. Three days later, levofloxacin was started because the patient’s symptoms did not improve. The novel coronavirus nucleic acid test was negative. It was noted that before the onset of the disease, the patient went to Wuhan on a business trip. Despite the given treatment, her body temperature rose to 39.2°C and she was referred to our clinic for further evaluation. Then, chest computed tomography was performed and showed bilateral multifocal ground glass opacities with consolidation which suggested viral pneumonia as a differential diagnosis, and the subsequent 2019-novel coronavirus pneumonia nucleic acid test was positive.