Acetabular retroversion results in reduced range of motion, and is thought to contribute to femoroacetabular impingement. Severe retroversion can be corrected with a periacetabular osteotomy, which is a technically demanding intervention. In this study, we investigated whether increasing femoral antetorsion is a potential alternative to restore the range of motion and how this approach would affect hip joint loading.
 
  Six different finite element models of the same subject were built from MRI and used to simulate different load scenarios during stance phase, including healthy and pathological configurations with different acetabular version and femoral torsion angles. The subject's gait was analysed in our gait lab and motion data as well as joint reaction forces were integrated into the model. Hip range of motion, hip abductor muscle forces as well as localization and magnitude of hip joint loads were determined.
 
  The negative effects of acetabular retroversion on hip range of motion including flexion and internal rotation can be reversed by increasing femoral anteversion. The rotation of the femur furthermore affected muscular functionality by shortening the moment arms of the hip abductor muscles, resulting in increased abductor muscle forces, joint reaction forces and hip joint loading.
 
  Even though increased femoral antetorsion can compensate for the loss of hip range of motion due to reduced acetabular version, rotational ostotomy of the proximal femur is likely to alter muscular moment arms and therefore increase hip joint load, conflicting the goal of a long-term healthy joint.
 Even though increased femoral antetorsion can compensate for the loss of hip range of motion due to reduced acetabular version, rotational ostotomy of the proximal femur is likely to alter muscular moment arms and therefore increase hip joint load, conflicting the goal of a long-term healthy joint.
  To understand the incidence and burden of injury of student-athletes in four of the most popular collegiate sports.
 
  Prospective cohort study.
 
  Collegiate sport.
 
  Gaelic football, hurling/Camogie, soccer and Rugby (n=672; male=416, female=256) student-athletes.
 
  Injury incidence, burden of injury and total, match and training injury rates, and their 95% confidence intervals were calculated. The frequencies and proportions were also calculated. An injury was defined as any physical condition that prevents a student-athlete from full participation for a period greater than 24h.
 
  Over a quarter (0.266) of student-athletes sustained an injury in the academic season. Male student-athletes had a higher injury rate than females (21.6 vs 11.3 injuries/1000h). Rugby (20.8 injuries/1000h) had the highest injury rates with hurling/Camogie (6.3 injuries/1000h) the lowest. Lower extremity injuries were predominant (68.8%) with ankle sprains demonstrating a large burden for all sports (20.6-280.2 days absent/1000h). Hamstring strains (13.7-118.4 days absent/1000h) had a large burden for all sports except male Rugby. Knee sprains had a large burden on the female Gaelic footballer (84.8 days absent/1000h). Sprinting (27.4%) and the tackle (20.1%) were the most common mechanism of injury. Injuries were predominantly moderate (8-28 days) or severe (>28 days) (84.7%).
 
  Injury reduction needs to be prioritised in the student-athlete, particularly in males. Specific focus is required on the lower extremity, especially in the hamstring muscles and ankle joint owing to the large burden of injury.
 Injury reduction needs to be prioritised in the student-athlete, particularly in males. Specific focus is required on the lower extremity, especially in the hamstring muscles and ankle joint owing to the large burden of injury.
  To determine the clinical profile of axial psoriatic arthritis (PsA) in a worldwide setting. Secondly, to identify factors associated with the development of axial involvement in patients with PsA.
 
  Data from 3684 patients with axial spondyloarthritis (axSpA) or PsA from the ASAS-perSpA study were analysed. The ASAS-perSpA is a cross-sectional study that recruited consecutive patients with SpA (as diagnosed by their rheumatologist) from 68 centers worldwide and collected patient and disease data. First, 2651 axSpA patients and 367 PsA patients with any history of axial involvement (axPsA) were compared using logistic regression to later identify predictive factors for rheumatologist diagnosis of axPsA. Secondly, 367 axPsA patients were compared with 666 PsA patients lacking axial involvement (peripheral PsA [pPsA]) and the characteristics associated with axial manifestations were explored by logistic regression analysis.
 
  Patients with axPsA were older and less frequently males or HLA*B27 positive in comparison with axSpA patients. Additionally, while patients with axPsA had more peripheral manifestations and psoriasis, other extra-musculoskeletal manifestations (IBD and uveitis) were more frequent in those with axSpA. In the multivariable analysis, older age at diagnosis (OR=1.04), peripheral arthritis (OR=7.32) and dactylitis (OR=2.82) were significantly associated with the diagnosis of axPsA. However, uveitis (OR=0.22), IBD (OR=0.12), HLA*B27 carriership (OR=0.26) or sacroiliitis on imaging (OR=0.5) were inversely associated with axPsA diagnosis as compared to axSpA. Axial involvement in patients with PsA was significantly associated with male gender (OR=1.68), elevated CRP (OR=2.87) and the absence of psoriasis (OR=0.33).
 
  In this worldwide setting axPsA was defined by rheumatologists as a unique phenotype, with disease features lying between axSpA and pure pPsA.
 In this worldwide setting axPsA was defined by rheumatologists as a unique phenotype, with disease features lying between axSpA and pure pPsA.
  The 2019 ACR/EULAR Classification Criteria for IgG4-related disease (IgG4-RD) represent a fundamental tool for patient enrollment in research studies and in clinical trials but their usefulness in daily clinical practice remains unknown.
 
  To validate the 2019 ACR/EULAR Classification Criteria for IgG4-RD in a real-life setting and to anticipate their utility for orienting disease diagnosis and patient management.
 
  Four experts were asked to classify 200 patients diagnosed with IgG4-RD according to the 2019 ACR/EULAR Classification Criteria for IgG4-RD.  https://www.selleckchem.com/products/hg-9-91-01.html  Agreement between experts was calculated and the Classification score of each patient was correlated with the following variables and outcomes serum IgG4 and IgE; inflammatory markers; eosinophils; plasmablasts; IgG4-RD responder index; diabetes, osteoporosis, relapses; and use of rituximab.
 
  Among the 157/200 cases equally rated by at least three experts, 94 (59.9%) achieved IgG4-RD classification and 63 (40.1%) did not. Strong agreement among IgG4-RD experts was observed in classifying patients (k=0.