https://www.selleckchem.com/products/ly3214996.html Here, the potential of C36, C48, and Ge48 nanocages as anodes of Na-ion battery (IB) and K-IB are investigated by DFT/M06-2X and DFT/B3LYP in gas and solvent. The EFormation and EGap of C36, C48, and Ge48 nanocages are investigated by theoretical methods. The vertical and adiabatic EA and IP of C36, C48, and Ge48 nanocages are examined in gas and solvent. The Ead of Na+ and K+ on inner and outer positions of C36, C48, and Ge48 nanocages are investigated. The Vcell and CTheory of C36, C48, and Ge48 as anodes of batteries are investigated. The results of this paper proposed the nano materials (C48 and Ge48 nanocage) as anodes of Na-IB and K-IB with higher CTheory and Vcell than graphene nanosheet. Anaplastic lymphoma kinase (ALK) gene rearrangement exists in approximately 3-7% of non-small cell lung cancer (NSCLC) and more than 15% split or isolated red signals among 50 tumor nuclei scored in the FISH analysis defines as ALK-positive. The previous studies showed that the high EGFR mutational load related to better outcomes in EGFR mutant NSCLC. Therefore, we aimed to investigate the effect of the ALK break-apart ratio on treatment outcome in metastatic ALK-positive NSCLC. The patients (pts) who ALK-positive and treated with crizotinib were retrospectively enrolled. The 30%, 40%, 50%, 60%, and 70% break-apart ratios were determined as a threshold value, and each of these was evaluated separately. Based on the results of these analyses, we detected the optimal threshold value and also performed further investigations. A total of 70 patients were enrolled in the study. The most significant decrease in the risk of the progression or death was detected at the 50% threshold value and it was accepted as.9 vs. 7.06 months (mo) in the pts with high ALK rearrangement than low (HR 0.43, 95% CI 0.24-0.76, p 0.004). The median OS was also significant longer in high ALK rearrange group (44.6 mo vs. 16.8 mo; HR 0.37, 95% Cl 0.1883-