Since its discovery, Helicobacter pylori (H. pylori) has attracted attention in the biomedical world with its numerous pathophysiologic implications, both gastrointestinal and systemic. Beyond its well-established carcinogenic properties, emerging evidence also supports "harmful" proinflammatory and neurodegenerative roles of H. pylori. On the other hand, H. pylori infection has been proposed to be "protective" against several diseases, such as asthma and gastroesophageal reflux disease. Eosinophilic esophagitis (EoE) is a relatively new, allergen/immune-mediated disease, which has also been linked to these considerations. Main arguments are a postulated shift of immune responses by H. pylori from T helper 2 (TH 2) to TH 1 polarization, as well as a potential decline of the H. pylori burden with the dramatic parallel rise of ΕοΕ a series of observational studies reported an inverse association. In this review, we counter these arguments by providing further epidemiological data, which point out that this generalization might be rather incomplete. We also discuss the limitations of the existing studies evaluating a possible association. Furthermore, we provide current evidence on common pathogenetic components, which share both entities. In summary, the claim that H. pylori is protective against EoE is rather incomplete, and further mechanistic studies are necessary to elucidate a possible association.Osteogenesis imperfecta (OI) is a group of inherited disorders with increased bone fragility and wide genetic heterogeneity. We report the outcome of clinical exome sequencing validated by Sanger sequencing in clinically diagnosed 54 OI patients in Indian population. In 52 patients, we report 20 new variants involving both dominant and recessive OI-specific genes and correlate these with phenotypes. COL1A1 and COL1A2 gene variants were identified in 44.23%, of which 28.84% were glycine substitution abnormalities. Two novel compound heterozygous variants in the FKBP10 gene were seen in two unrelated probands. A novel heterogeneous duplication of chromosomal region chr17 48268168-48278884 from exons 1-33 of the COL1A1 gene was found in one proband. In five probands, there were additional variants in association with OI. These were ANO5 in association with CRTAP in two probands of the same family causing gnathodiaphyseal dysplasia, COL5A2 with LEPRE1 causing Ehlers Danlos syndrome, COL11A1 in addition to COL1A1 causing Stickler syndrome, and a previously unreported combination of SLC34A1 gene variant with FKBP10 leading to Fanconi renal tubular syndrome type II.  https://www.selleckchem.com/products/cytidine-5-triphosphate-disodium-salt.html  Our findings demonstrate the efficacy of clinical exome sequencing in screening OI patients, classifying its subtypes, and identifying associated disorders in consanguineous populations.
  Psychological first aid (PFA) is utilized in the direct aftermath of crisis events. As the world grappled with Covid-19, PFA was provided for staff members in Hospital Sultan Ismail. In adherence to the New Normal, innovative approaches had to be taken. We engaged clients through virtual communication methods. PFA Solat was organized to assist Muslim staff fulfil religious obligations while being on the frontlines.
 
  PFA may be useful in helping frontline staff manage stress associated with the increased workload and general anxiety relating to the pandemic.
 
  It is recommended all staff members, especially those involved in frontline duty, to be provided PFA.
 It is recommended all staff members, especially those involved in frontline duty, to be provided PFA.Many studies have focused on heart rate variability in association with ventilatory thresholds. The purpose of the current study was to consider the ECG-derived respiration and the high frequency product of heart rate variability as applicable methods to assess the second ventilatory threshold (VT2). Fifteen healthy young soccer players participated in the study. Respiratory gases and ECGs were collected during an incremental laboratory test and in a multistage shuttle run test until exhaustion. VΤ2 was individually calculated using the deflection point of ventilatory equivalents. In addition, VT2 was assessed both by the deflection point of ECG-derived respiration and high frequency product. Results showed no statistically significant differences between VT2, and the threshold as determined with high frequency product and ECG-derived respiration (F(2,28)=0.83, p=0.45, η2=0.05). A significant intraclass correlation was observed for ECG-derived respiration (r=0.94) and high frequency product (r=0.95) with VT2. Similarly, Bland Altman analysis showed a considerable agreement between VT2 vs. ECG-derived respiration (mean difference of -0.06 km·h-1, 95% CL ±0.40) and VT2 vs. high frequency product (mean difference of 0.02 km·h-1, 95% CL ±0.38). This study suggests that, high frequency product and ECG-derived respiration are indeed reliable heart rate variability indices determining VT2 in a field shuttle run test.Bioelectrical impedance analysis equations for fat-free mass prediction in healthy populations exist, nevertheless none accounts for the inter-athlete differences of the chemical composition of the fat-free mass. We aimed to develop a bioimpedance-based model for fat-free mass prediction based on the four-compartment model in a sample of national level athletes; and to cross-validate the new models in a separate cohort of athletes using a 4-compartment model as a criterion. There were 142 highly trained athletes (22.9±5.0 years) evaluated during their respective competitive seasons. Athletes were randomly split into development (n=95) and validation groups (n=47). The criterion method for fat-free mass was the 4-compartment model. Resistance and reactance were obtained with a phase-sensitive 50 kHz bioimpedance device. Athletic impedance-based models were developed (fat-free mass=- 2.261+0.327*Stature2/Resistance+0.525*Weight+5.462*Sex, where stature is in cm, Resistance is in Ω, Weight is in kg, and sex is 0 if female or 1 if male). Cross validation revealed R2 of 0.94, limits of agreement around 10% variability and no trend, as well as a high concordance correlation coefficient. The new equation can be considered valid thus affording practical means to quantify fat-free mass in elite adult athletes.