This study present real-time measurements of the chemical composition and particle number size distributions (PNSD) of submicron particulate matter (PM1) in winter at a coastal industrial park in the Yangtze River Delta region of China. Positive matrix factorization (PMF) analysis identified three PNSD factors and three organic aerosol (OA) factors. Contributions and potential source regions of these factors were investigated for four typical periods during the PM1 formation and dissipation process. Results show that the relative contributions from aged 250 nm- factor, fresh 35 nm- and 80 nm- factors were strongly affected by local fresh emissions and regional new particle formation. The non-refractory PM1 measured by Aerodyne aerosol chemical speciation monitor is indicative of the chemical composition of aged 250 nm-factor, but not fresh 35 nm- and 80 nm-factors. The contributions of NO3- and SO42- to NR-PM1 were largely dictated by whether the air mass trajectory went over the sea or the continent. NO3- was abundant (up to 44% of NR-PM1) in cold and dry continental air masses, while SO42- formation (up to 39% of NR-PM1) was preferred in humid and warm marine air masses. Among the three OA source factors, more-oxidized oxygenated OA (MO-OOA) was the most abundant OA factor (44-66% of total OA) throughout the entire field campaign, while an enhanced contribution of 39% from hydrocarbon-like OA (HOA) was observed prior to heavy pollution period. On average, secondary components SO42-, NO3-, NH4+, MO-OOA and less-oxidized oxygenated OA (LO-OOA) contributed 90 ± 7% of NR-PM1, while primary components HOA and Cl- accounted for the remaining 10 ± 7%.Providing enough food for the increasing global population is difficult due to water shortages, which can be partially resolved by regulating soil moisture. Soil moisture influences soluble nutrient uptake and microbial activity, which determine crop growth, but also affects greenhouse gas (GHG) emissions. Farming is increasingly contributing to GHG emission, but little is known about the effects of the vertical soil moisture distribution on GHG or maize (Zea mays L.) yield over the growth season. In this study, there were five irrigation treatments no irrigation (NI), and irrigation of the top (0-30 cm) (TI), middle (30-60 cm) (MI), bottom (60-90 cm) (BI), and all (0-90 cm) (AI) soil layers. The results showed that TI, MI, BI, and AI increased CO2 (25-60%), CH4 (80-270%), and N2O (17-96%) emissions, and the global warming potential (25-63%), while also increasing grain yield (13-119%) and reducing GHG intensity by 12-27%. While higher soil moisture in the shallow soil layer increased grain yield and GHG emissions, GHG intensity was lowest. Subsurface irrigation or control of the "drip irrigation interval" improve grain yield and resource use efficiency with lower environmental costs contributing agricultural sustainable development.Existing methods for RNA diagnostics, such as reverse transcription PCR (RT-PCR), mainly rely on nucleic acid amplification (NAA) and RT processes, which are known to introduce substantial issues, including amplification bias, cross-contamination, and sample loss. To address these problems, we introduce a confinement effect-inspired Cas13a assay for single-molecule RNA diagnostics, eliminating the need for NAA and RT. This assay involves confining the RNA-triggered Cas13a catalysis system in cell-like-sized reactors to enhance local concentrations of target and reporter simultaneously, via droplet microfluidics. It achieves >10 000-fold enhancement in sensitivity when compared to the bulk Cas13a assay and enables absolute digital single-molecule RNA quantitation. We experimentally demonstrate its broad applicability for precisely counting microRNAs, 16S rRNAs, and SARS-CoV-2 RNA from synthetic sequences to clinical samples with excellent accuracy. Notably, this direct RNA diagnostic technology enables detecting a wide range of RNA molecules at the single-molecule level. Moreover, its simplicity, universality, and excellent quantification capability might render it to be a dominant rival to RT-qPCR.Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune paraneoplastic syndrome associated with ovarian teratomas. Most patients develop neurologic symptoms, including psychosis, memory deficits, seizures, or abnormal movements, and experience abdominal pain related to ovarian neoplasm. We present a case report of three patients diagnosed with anti-NMDAR encephalitis accompanied by ovarian teratomas at Ajou University Hospital in Korea. The patients demonstrated a different clinical course of the disease. However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. The symptoms progressively improved following treatment. This is a case report of a rare autoimmune anti-NMDAR encephalitis associated with ovarian neoplasms, including immature teratoma.COVID-19 is an important public health issue of great concern at home and abroad, and it is still in the state of global pandemic. During the normalization stage of prevention and control of the epidemic of COVID-19, China effectively controlled the outbreak and spread of the epidemic by adopting the strategy of "import of external prevention and rebound of internal prevention", and effectively reduced the occurrence of death cases. The social economy recovered quickly, and various measures were highly recognized by the public, and the positive trend of the epidemic continued to consolidate.  https://www.selleckchem.com/products/Streptozotocin.html  At present, although the spread of the local epidemic has been basically stopped, the international epidemic continues to rise rapidly, and the pressure of "imported prevention and control" in China continues to increase. Considering the characteristics of the normalization of epidemic prevention and control and the particularity of the virus, the connotation of the normalization of epidemic prevention and control should be understood scientifically. The prevention and control goal of the epidemic in the normalization stage should be to maximize early detection, early treatment and early disposal, and resolutely prevent the continuous spread of the epidemic in communities, that is, to prevent the infection as much as possible, and resolutely prevent the rebound (sustained spread in communities), rather than "zero infection". The prevention and control policy of "timely detection, rapid disposal, precise management and control, and effective treatment" has been implemented in various localities, and a series of effective and regular experience in prevention and control has been formed in the practice of prevention and control. Winter and spring are the key periods for the prevention and control of the epidemic. We should continue to work together to prevent and control the epidemic, fulfill the responsibilities of all parties, and prevent and control the epidemic in a scientific and effective way.