https://www.selleckchem.com/products/Cyclopamine.html Surgical and endovascular revascularization procedures along with hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) for chronic oxygen-deprived wounds are standard care treatment protocols for diabetic foot ulcer (DFU). Topical developments in the delivery of topical oxygen therapy have made this a more feasible treatment in practice. The present case series highlights the efficacy of NATROX therapy as TOT in wound healing and the impact of increased oxygenation on ulcer healing in patients with diabetic foot ulcers. <P> Methods The TOT was evaluated in 6 patients with DFU who have applied NATROX topical oxygen delivery system for a period ranging from 6 weeks to 24 weeks at Kahel Specialized Centre, located in Olaya, Riyadh, Saudi Arabia. <P> Results The administration of TOT demonstrated complete wound healing in all the six patients who either had ulcers with minor amputation of toes/heel ulcer or had ulcers other comorbidities with a range from 3 to 8 weeks. <P> Conclusion NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races. Conclusion NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races. Although hyperglycaemia is known to be the leading cause of the diabetic complications, the beneficial effect of an optimal glucose control on the prevention of diabetic complications is still far from being proven. In fact, such complications may not to be related to glycaemic control alone. <P> Objective This review summarizes several studies that suggest that a C-peptide deficiency cou