https://www.selleckchem.com/products/erastin.html 001) and BFR group (-3 ± 2%; p = 0.001), but not in the BFR+EMS group (-0.3 ± 3%; p = 0.8). VL muscle thickness decreased in the control group (-4 ± 4%; p = 0.005), and was trending toward a decrease in the BFR group (-8 ± 11%; p = 0.07) and increase in the BFR+EMS group (+5 ± 10%; p = 0.07). Knee-extension MVC decreased over time (p < 0.005) in the control (-18 ± 15%), BFR group (-10 ± 13%), and BFR+EMS (-18 ± 15%) group, with no difference between groups (p > 0.5). Unlike BFR performed in isolation, BFR+EMS represents an effective interventional strategy to attenuate the loss of muscle mass during limb disuse, but it does not demonstrate preservation of strength. Unlike BFR performed in isolation, BFR+EMS represents an effective interventional strategy to attenuate the loss of muscle mass during limb disuse, but it does not demonstrate preservation of strength. This study aimed to evaluate the effects of low energy availability (EA) on health and performance indices associated with the Male Athlete Triad and Relative Energy Deficiency in Sport (RED-S) models. Over an 8-wk period, a male combat sport athlete adhered to a phased body mass (BM) loss plan consisting of 7-wk energy intake (EI) equating to resting metabolic rate (RMR) (1700 kcal·d-1) (phase 1), 5 d of reduced EI (1200-300 kcal·d-1) before weigh-in (phase 2), and 1 wk of ad libitum EI postcompetition (phase 3). EA fluctuated day by day because of variations in exercise energy expenditure. Regular assessments of body composition, RMR, cardiac function, cardiorespiratory capacity, strength and power, psychological state and blood clinical chemistry for endocrine, bone turnover, hydration, electrolyte, renal, liver, and lipid profiles were performed. BM was reduced over the 8-wk period by 13.5% (72.5 to 62.7 kg). No consequences of Male Athlete Triad or RED-S were evident during phase 1, where mean dail of five consecutive days of EA less then 10 kcal·kg FFM