Childhood abuse appears to influence young adult relationship functioning through mental health problems in mid-adolescence, particularly anger and dissociation. These results are consistent with the notion that children who were abused may struggle in romantic relationships in young adulthood and addressing mental health problems in adolescence may a point of intervention.The United Kingdom parliament made history in 2015 when they voted to allow the use of mitochondrial (mtDNA) replacement techniques. Mitochondrial diseases are genetically inherited and currently, the only known cure is replacement therapies. However, most other countries have been slow to adopt policy changes that allow for mtDNA replacement due to the ethical challenges of the techniques. While there are ethical challenges concerning mtDNA replacement, there is a need to address these challenges and allow these techniques in the US to provide treatment for individuals affected. This paper first addresses mitochondrial diseases and replacement techniques currently used and analyzes ethical challenges related to the interventions, such as safety, efficacy, and contributed genetic material from three individuals. This paper then addresses how the ethical principles, beneficence, nonmaleficence, autonomy and justice support mtDNA replacement. Suggestions on how the US can allow mtDNA replacement by adopting similar policy changes to the UK are provided, as well as additional measures to protect patients. Given the rate of individuals affected, severity of mitochondrial diseases, and lack of treatment options available, it's important to address how to overcome ethical challenges and policy barriers.Background Universal Health Coverage has become a political priority for many African countries yet there are clear challenges in achieving this goal. Though social health insurance is considered a mechanism for providing financial protection, less well documented in the literature is evidence from countries in Africa who are at various stages of adopting this financing strategy as a way to improve health insurance coverage for their populations. Objectives The study investigates whether social health insurance schemes are effectively and efficiently covering all groups. The objective is to provide evidence of how these schemes have been implemented and whether the fundamental goals are met. The selected countries are Ghana, Rwanda, Tanzania, Kenya and Ethiopia. The study draws lessons from the literature about how policy tools can be used to reduce financial barriers whilst ensuring a broad geographic coverage in Africa. Methods The study relies primarily on a review of literature, both documented and grey mlso, highly fragmented risk pools impede efforts to widen the insurance pools and promote cross-subsidies.The study aimed to determine the prevalence of continuity of illicit drug use and its associated factors among Malay opioid users receiving methadone treatment in Kelantan, Malaysia. This cross-sectional study involved a total of 150 respondents. Sociodemographic characteristic of participants, level of religiosity, and quality of life were collected using the self-administered questionnaires. The prevalence of continuity illicit drug use was 38.7% (n = 58) by self-report and 40.7% (n = 61) by positive urine test result for drugs. Positive hepatitis C status and high quality of life in the psychological health domain were associated with low continuity of illicit drug use by self-reported data and urine drug test results. In conclusion, the continuity of illicit drug use among methadone program users is still high, especially among those on methadone therapy for less than 2 years.
  There are an increasing number of studies indicating the important roles served by long non-coding RNAs (lncRNAs) in the development of different types of cancer.  https://www.selleckchem.com/screening-libraries.html  LINC00460 is a novel identified lncRNA that was found to be upregulated in colorectal cancer. However, the biological roles of LINC00460 in colorectal cancer have yet to be fully elucidated. This study was aimed to investigate the functions and molecular mechanisms of LINC00460 on colorectal cancer metastasis.
 
  Expression of LINC00460 and 
  in colorectal cancer tissues and cell lines were quantified by real time PCR or western blotting assay. Cell migration and invasion assays were performed to determine the effect of LINC00460 on tumor metastasis in vitro. The binding interaction between microRNA-149-5p and LINC00460 was revealed by luciferase reporter assay.
 
  In the present study, lncRNA LINC00460 was shown to be upregulated in colorectal cancer tissues, and overexpression of LINC00460 significantly promoted metastasis of colorectal cancer in vitro. Furthermore, miR-149-5p interacted with LINC00460, and they negatively regulated expression of each other. Transfection of miR-149-5p mimics partially counteracted the tumor metastasis-promoting effects induced by LINC00460 overexpression. Finally, overexpression of LINC00460 upregulated the expression levels of 
  , a target gene of miR-149-5p, which has also been identified as an oncogenic driver in colorectal cancer.
 
  Taken together, the present study demonstrated that LINC00460 promoted metastasis of CRC by sponging miR-149-5p and thereby affecting 
  expression levels.
 Taken together, the present study demonstrated that LINC00460 promoted metastasis of CRC by sponging miR-149-5p and thereby affecting biglycan expression levels.Touch is an important element of human social interaction linked to various dimensions of well-being, but we know little of how it is distributed among older adults. This study considers whether greeting/affectionate touch is a function of characteristics such as race, gender, and socioeconomic status. Data come from Wave 1 (2005-2006) of the NSHAP study from the United States. Results reveal that women experienced more frequent touch relative to men, net of several features of the interpersonal environment. Mediation analyses revealed that gender differences in associations with touch were partially explained by women's greater participation in formal and informal social activity. No patterns were detected related to race, education, or wealth. This study situates greeting/affectionate touch as a form of corporeal non-verbal interaction that offers a unique lens into patterns of social connection. We close by considering what this form of interaction means in the wake of the COVID-19 pandemic.