0. Three large linkage disequilibrium blocks and the corresponding haplotypes were found to be associated with significant SNPs. In total, 37 candidate genes with nine genes having a putative role in disease resistance (F-box-like domain superfamily, Leucine-rich repeat, cysteine-containing subtype, Cytochrome P450 superfamily, Zinc finger C2H2-type, RING/FYVE/PHD-type, etc.) were identified. Genomic selection was conducted to investigate how well one could predict the phenotype of the nematode count without performing the screening experiments. Prediction value of r = 0.40 to 0.44 was observed when 56 to 70% of the population was used as a training set. This is the first report where GWAS has been conducted to find resistance against root lesion nematode (P. thornei) in Indian wheat germplasm.Natron-based glass was a vital part of material culture in the Mediterranean and Europe for nearly two millennia, but natron glass found elsewhere on the Eurasian Continent has not received adequate discussion, despite its influence on ancient Asian glass. Here we present a new interpretation of natron glass finds from both the West and the East. After establishing the compositional types and technological sequence of Mediterranean natron glass (eighth-second century BCE) using trace elements, we report the analysis of a mid-1st millennium BCE glass bead from Xinjiang, China, which was likely made with Levantine raw glass, and identify common types of stratified eye beads in Eurasia based on a compositional and typological comparison. Combining these findings, we propose that a considerable number of Mediterranean natron glass products had arrived in East Asia at least by the fifth century BCE, which may have been a contributing factor in the development of native Chinese glass-making. The swift diffusion of natron glass across Eurasia in the 1st millennium BCE was likely facilitated by a three-stage process involving maritime and overland networks and multiple forms of trade and exchange, indicating a highly adaptable and increasingly efficient transcontinental connection along the 'Proto-Silk Road'.The key purpose of the existing article is to discuss the effects of various hybrid nanofluids and a simple nanofluid over the heat transfer and friction drags along a stretched surface. The various kinds of hybrid nanofluids and a simple nanofluid together with the effects of aligned magnetic field, nonlinear radiation and suction have been taken into consideration.  https://www.selleckchem.com/products/ro-3306.html  These hybrid nanofluids are prepared by suspending a couple of distinct nanoparticles [Formula see text] and [Formula see text] into the base fluids [Formula see text] and [Formula see text]. The comparison of various graphical results of skin friction coefficient, rate of heat transfer, velocity and temperature for two different hybrid nanofluids [Formula see text]/[Formula see text], [Formula see text]/[Formula see text] and a simple nanofluid [Formula see text]/[Formula see text] is considered. Moreover, the impact of surface stretching, aligned magnetic field and thermal radiation over the velocity, temperature, skin friction coefficient and local Nusselt number are also considered. The outcomes drawn from this modern research is that the hybrid nanofluid [Formula see text]/[Formula see text] is quite effective in cooling and heating in comparison to the other hybrid nanofluids [Formula see text]/[Formula see text], [Formula see text]/[Formula see text] and a simple nanofluid [Formula see text]. Based on these findings we could say that the suspension of multiple particles in the composition of two or more base fluids provides a better rate of heat transfer and limits the friction drag.Cyclone Fani, in April 2019, was the strongest pre-monsoon cyclone to form in the Bay of Bengal after 1994. It underwent rapid intensification and intensified quickly to an extremely severe cyclone. It maintained a wind speed of ≥ 51 m s-1 (≥ 100 knots) for a record time period of 36 h. The total lifespan of the cyclone was double than the climatological lifespan. Also, the duration of the cyclone in its extremely severe phase and the accumulated cyclone energy were significantly larger than the climatological records for the pre-monsoon season. In the current study, we investigate the ocean-atmospheric conditions that led to its genesis, rapid intensification and long lifespan. Our analysis shows that the Madden Julian Oscillation and anomalous high sea surface temperatures provided conducive dynamic and thermodynamic conditions for the genesis of cyclone Fani, despite forming very close to the equator where cyclogenesis is generally unlikely. Further, favourable ocean subsurface conditions and the presence of a warm core eddy in the region led to its rapid intensification to an extremely severe cyclone. A large area of warm ocean surface and subsurface temperatures aided the cyclone to maintain very high wind speed for a record time period. The vital role of the ocean surface and the subsurface in the genesis and the intensification highlights the need to efficiently incorporate ocean initial conditions (surface and sub-surface) and ocean-atmosphere coupling in the operational cyclone forecasting framework.Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester miscarriage were included and 1449 women were available as live birth controls. Eight PFASs were measured in first trimester serum. A doubling of perfluorooctanoic acid (PFOA) exposure, corresponding to an inter-quartile increase, was associated with an odds ratio (95%CI) for miscarriage of 1.48 (1.09-2.01) when adjusting for parity, age and smoking. Analyses per quartiles of PFOA exposure indicated a monotonic dose response association with miscarriage. A similar, but not significant, pattern was observed for perfluorononanoic acid (PFNA). For other PFAS, there were no associations with miscarriage. We have previously shown associations between early pregnancy PFAS exposures and preeclampsia, as well as lower birth weight.