https://www.selleckchem.com/products/l-kynurenine.html This systematic review (PROSPERO - CRD42020150722) was performed to answer the following question Does the use of chelating agents affect the dislodgment resistance of epoxy resin-based root canal sealers? A search was conducted in PubMed, EMBASE, Scopus, LILACS and Web of Science, hand searching of two endodontic journals and grey literature until September 2020. Extracted data included teeth used, sample size, root canal preparation, irrigant, chelating solution, neutralisation solution, type of resin-based sealer and obturation approach, storage method and duration, root third and slice thickness, plunger dimension and loading direction and the push-out testing parameters and values. The search retrieved a total of 2.389 studies. After analysis, 12 studies fulfilled the eligibility criteria and were included. Most of the final irrigation protocols with chelating agents had a positive impact and promoted an improvement in the dislodgment resistance of epoxy resin-based sealers to the root dentin. To systematically review current practices, strengths, and limitations of existing VA approaches to increase their understanding by health information systems stakeholders and researchers. The review was conducted and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, in which articles were systematically obtained from the PubMed and SCOPUS online databases. The search was limited to English language journal articles published between 2010 and 2020. The review identified 5602 articles and after thorough scrutiny, 25 articles related to VA approaches were included. (1) InterVA and Tariff are widely used VA models; (2) Bayes rule is the most common and successful algorithm; (3) the lack of standardized datasets and metrics to evaluate models creates bias in determining VA model performance; (4) performance of the models trained using in-hospital data cannot be r