https://www.selleckchem.com/products/ly3039478.html The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.Here we report a facile dye incorporation method for fluorescence encoded microbeads, which is achieved by tuning the mixed polymer type (blank and dye-labeled polymers) and their doping ratio through electrostatic loading into mesoporous beads. This method is universal to various carriers and could render large encoding capacities.Organophosphorus pesticides (OPs) residues have caused great concern as they cause great harm to public health. Herein, a ratiometric fluorescent sensing system was developed for the OPs detection with the merits of enzyme-free, simple operation, short-time and sensitivity. The change in the fluorescence signal in the sensing system was provided by guanine-rich DNA (G-DNA) and silver nanoparticles (AgNPs) with terbium ion (Tb3+) and dured. Tb3+ coordinated with the G-DNA to form a DNA-Tb complex to emit green fluorescence, which can be significantly enhanced by AgNPs based on the mechanism of metal enhanced fluorescence. Dured embedded into the G-DNA emits red fluorescence as the built-in fluorescence signal. After adding OPs into the DNA-Tb-dured-AgNPs sensing system, the fluorescence of Tb3+ quenched, while the fluorescence of dured remained unchanged. The OPs detection is implemented enzyme-free or label-free and has the advantage of high sensitivity and reliability. The limit of detection reaches as low as 0.034 μg L-1, and good recoveries are obtained for the OPs detection in tap water and apple. Moreover, the developed sensing system is simple in preparation and low cost, exhibiting an efficient platform to meet the requirement for i