h on speech articulation disorders in prosthesis wearers is needed.
 Given the low quality of evidence on speech articulation disorders, further research on speech articulation disorders in prosthesis wearers is needed.This clinical report describes the prosthetic restoration of a failing dentition subsequent to methamphetamine abuse. The treatment involved the use of endosteal dental implants and milled cobalt-chromium, screw-retained, implant-supported fixed dental prostheses. At the 1-year follow-up, the prosthetic rehabilitation had markedly improved the patients' health, esthetics, and function.This clinical report describes an approach for improving the esthetics and extending the service life of a cement-retained implant-supported ceramic single crown by using a ceramic veneer bonded to the conservatively prepared facial surface. The restoration satisfied the patient without removing and replacing the unesthetic implant-supported ceramic crown.
  Monolithic zirconia has become widely used for single crowns, with the advantages of minimal tooth reduction and good esthetics. However, clinical studies evaluating the performance of and patient satisfaction with posterior monolithic zirconia crowns are sparse.
 
  The purpose of this clinical study was to evaluate the clinical performance of and patient satisfaction with posterior monolithic zirconia crowns.
 
  Within a prospective cohort study design, participants were recruited from a university dental clinic if they required 1 posterior monolithic zirconia crown. The clinical performance was evaluated at follow-up appointments 1, 2, and 3 years after insertion. Bleeding on probing and pocket probing depths for the crowned teeth were recorded. Overall patient satisfaction was measured by using a visual analog scale (VAS), and quality of life was measured by using the validated German version of the Oral Health Impact Profile 14 (OHIP-G14). Descriptive statistical methods were applied.  https://www.selleckchem.com/products/zongertinib.html  Mean values were calere still in function. The gingival and the periodontal status of the crowned teeth had not changed significantly over the 3 years. After insertion, a significant improvement in patient satisfaction was measured up to 3 years CONCLUSIONS Posterior monolithic zirconia crowns led to enhanced patient satisfaction up to 3 years after insertion. They provided good middle-term success and offered a promising alternative to conventional metal-ceramic crowns.
  Whether procedures performed before the cementation of computer-aided design and computer-aided manufacturing (CAD-CAM) glass-ceramic restorations, including milling, fitting adjustment, and hydrofluoric acid etchingintroduce defects on the ceramic surface that affect the mechanical and surface properties is unclear.
 
  A systematic review and meta-analysis were conducted to assess the effect of milling, fitting adjustments, and hydrofluoric acid etching (HF) on the flexural strength and roughness (Ra) of CAD-CAM glass-ceramics.
 
  Literature searches were performed up to June 2020 in the PubMed/MEDLINE, Web of Science, and Scopus databases, with no publication year or language limits. The focused question was "Do milling, fitting adjustments, and hydrofluoric acid etching affect the flexural strength and roughness of CAD-CAM glass-ceramics?" For the meta-analysis, flexural strength and Ra data on milling, fitting adjustment, and HF etching versus control (polishing) were analyzed globally. A subgroup analysig adjustment. Ceramic microstructure, HF concentration, and etching time determined the effect of hydrofluoric acid etching on the flexural strength and surface roughness of glass-ceramic materials.
 The flexural strength of CAD-CAM glass-ceramic is reduced by grinding procedures such as milling and fitting adjustment. Ceramic microstructure, HF concentration, and etching time determined the effect of hydrofluoric acid etching on the flexural strength and surface roughness of glass-ceramic materials.
  It is unclear how preoperative neurodegeneration and postoperative changes in EEG delta power relate to postoperative delirium severity. We sought to understand the relative relationships between neurodegeneration and delta power as predictors of delirium severity.
 
  We undertook a prospective cohort study of high-risk surgical patients (>65 yr old) to identify predictors of peak delirium severity (Delirium Rating Scale-98) with twice-daily delirium assessments (NCT03124303). Participants (n=86) underwent preoperative MRI; 54 had both an MRI and a postoperative EEG. Cortical thickness was calculated from the MRI and delta power from the EEG.
 
  In a linear regression model, the interaction between delirium status and preoperative mean cortical thickness (suggesting neurodegeneration) across the entire cortex was a significant predictor of delirium severity (P<0.001) when adjusting for age, sex, and performance on preoperative Trail Making Test B. Next, we included postoperative delta power and repeated the analysis (n=54). Again, the interaction between mean cortical thickness and delirium was associated with delirium severity (P=0.028), as was postoperative delta power (P<0.001). When analysed across the Desikan-Killiany-Tourville atlas, thickness in multiple individual cortical regions was also associated with delirium severity.
 
  Preoperative cortical thickness and postoperative EEG delta power are both associated with postoperative delirium severity. These findings might reflect different underlying processes or mechanisms.
 
  NCT03124303.
 NCT03124303.There are significant concerns regarding prescription and misuse of prescription opioids in the perioperative period. The Faculty of Pain Medicine at the Royal College of Anaesthetists have produced this evidence-based expert consensus guideline on surgery and opioids along with the Royal College of Surgery, Royal College of Psychiatry, Royal College of Nursing, and the British Pain Society. This expert consensus practice advisory reproduces the Faculty of Pain Medicine guidance. Perioperative stewardship of opioids starts with judicious opioid prescribing in primary and secondary care. Before surgery, it is important to assess risk factors for continued opioid use after surgery and identify those with chronic pain before surgery, some of whom may be taking opioids. A multidisciplinary perioperative care plan that includes a prehabilitation strategy and intraoperative and postoperative care needs to be formulated. This may need the input of a pain specialist. Emphasis is placed on optimum management of pain pre-, intra-, and postoperatively.