The research opens new research paradigm for studying the antecedents of the original determinants of intention through indirect path analyses. Applying these findings can reduce the reliance on public sector for employment. It could equally create jobs that could reduce societal crisis through employment into privately owned businesses.The aim of this study is to examine the molecular mechanism of cytotoxicity caused by direct exposure to short chain alcohol. We showed previously that exposing H9c2 cardiomyoblastoma cells to 150 mM 1-butanol results in cell death within 1 h through an intrinsic apoptotic pathway. The cell death is accompanied by plasma membrane blebbing and caspase-3 activation. Here we show that a higher concentration (200 mM) of 1-butanol, as well as prolonged exposure (3-6 h) to 150 mM 1-butanol, induces plasma membrane ballooning, a characteristic feature of pyroptosis. Although gasderminD (GSDMD) cleavage by caspase-1 was not observed, GSDME cleavage by caspase-3 was observed during exposure to 150 mM 1-butanol for 6 h. We conclude that pyroptotic cell death by 1-butanol in H9c2 cardiomyoblastoma cells should occur via the caspase-3-GSDME pathway, revealing that 1-butanol could induce not only apoptosis but also pyroptosis in the cells.This research was intended to investigate the structural feature, antioxidative activity and interaction with β-lactoglobulin (β-lg) of a polysaccharide (P) isolated from Borassus flabellifer fruit thru aqueous extraction, protein elimination and chromatographic techniques. Polysaccharide P (molecular weight 21,000 g mol-1) was constituted of arabinose, galactose, glucose, and rhamnose in a 5024206 M ratio alongside 9% (w/w) galacturonic acid. It encompassed a petite backbone entailing galacturonopyranosyl and rhamnopyranosyl units substituted with sizable side chains comprising of arabinofuranosyl, galactopyranosyl and esterified coumaric acid (CA) residues. Various series of oligosaccharides including (i) Gal1,2,4-9Ac5-29, (ii) Ara2-3Ac6-8, (iii) Gal3Ara1-3Ac13-17, (iv) Gal4-6Ara2Ac18-24, (v) Gal6Ara1Ac22 and (vi) Gal1Ara2CA1Ac7 and Gal1Ara3CA1Ac9 epitomizing polysaccharide structure were generated and characterised. Fraction P exhibited dose-dependent antioxidant activity and possessed a strong β-lactoglobulin binding capability. Accordingly, B. flabellifer fruit offers an antioxidative polysaccharide having novel structure that can associate with β-lg and, hence, useful in formulating novel food possessing adjustable composition.This study evaluated the nutritional composition of Nigeria's lesser known legumes namely African breadfruit (Treculia africana), African yam bean (Sphenostylis stenocarpa) seed, bambaranut (Vigna subterranean L.), red bean (Phaseolus vulgaris), groundnut (Arachis hypogea L.), African oil bean (Pentaclethra mycrophylla Benth.) seed, cowpea (Vigna unguiculata (L.) Walp) and pigeon pea (Cajanus cajan).  https://www.selleckchem.com/products/quinine-dihydrochloride.html  The proximate composition, mineral content, fibre profile, fatty acid profile and amino acid compositions were evaluated using standard methods. The results showed that legume samples vary significantly (p less then 0.05) in the chemical parameters evaluated. Groundnut, African oil bean seed and African breadfruit had significantly higher protein, carbohydrate, fat and ash contents than other legumes. Equally, groundnut, African oil bean and African breadfruit showed superiority in mineral and fibre abundance, while bambaranut had the lowest mineral and fibre contents. Linolenic acid is the most abundant fatty acid in all the legumes with values ranging from 38.78 - 84.57%. The percentage polyunsaturated fatty acid (PUFA) for all the samples ranged from 40.15 - 48.97%. The total essential amino acids ranged from 24.11 - 66.67 mg/100 g. The range is considered adequate for ideal protein food. Therefore, lesser legumes evaluated can serve as alternative protein sources with good minerals, fibre, essential fatty and amino acids contents.Migration is a central component of both individual life-courses and macro-level demographic systems. In the absence of population registers and other surveillance systems, however, it is often difficult to measure. This is especially the case in historical populations. Compared to measures of fertility, nuptiality and mortality, then, migration processes are rather less studied. Recent studies in the English historical context have challenged long standing theoretical constructs concerning the relationship between migration and modernisation; gender and distance travelled; motivation for movement and the very nature of the movers themselves. Using a set of marriage registers for a large, agricultural county, this study explores intra-county migration among a predominantly young population over the period 1700 to 1836. The proportion of migrants is explored as well as the distance between 'home' and 'marriage' parishes. For perhaps the first time, chord diagrams are deployed for historical English migration data to visualise inter- and intra- regional/district migration. Although there are numerous limitations concerning the scope of the sample and the study, the evidence presented here broadly accords with recent studies of migration in pre-industrial England; and shows the potential to both use circular visualisation and exploit large scale samples of marriage registers to gain a further insight into a particular type of historical migration.Histories of medicine and vaccinology routinely reference the Ottoman Empire with regard to Lady Mary Wortley Montagu, her children's variolation, and the transmission of this knowledge throughout Britain and thereafter Europe. Few, however, follow the empire's ongoing relationship with vaccination after the Montagu family's departure. This article examines this aspect of Ottoman medical history by noting how Jenner's advances diffused back into the empire and then presenting and analyzing how imperial, medical, and even community leaders began to both educationally condition the population and gradually enact legislation that mandated vaccination. Owing to severe infrastructural, personnel, and financial deficits, instability, and popular fears and trepidation, the empire's aspirations to achieve universal vaccination were far from realized by the time of its early 1920s demise-especially throughout largely rural Anatolia. Ottoman institutional, educational, and legislative advances, however, collectively prepared the ground for the succeeding Turkish republic and its public health agenda.