Brain-derived neurotrophic factor (BDNF) is a pro-survival factor in the brain that also regulates energy balance. 
  loss-of-function point mutations are responsible for haploinsufficiency, causing severe early-onset obesity. Up to date, only a few studies have sequenced this gene to search for rare mutations related to obesity. In this study, we aimed to investigate the prevalence of 
  variants in a cohort of adults with severe obesity from Brazil.
 
  This study comprised 201 adults with severe obesity (BMI ≥ 35.0 kg/m
  ) with onset during childhood- or adolescence/youth. As controls, 73 subjects with normal weight (18.5 ≤ BMI ≤ 24.9 kg/m
  ) were selected. The exclusion criteria were pregnancy, lactation, the use of medication to lose or gain weight, and the presence of symptoms suggestive of syndromic obesity (only for the case group). The coding region of the 
  gene was screened by Sanger sequencing. Demographic, anthropometric, and blood pressure parameters were obtained from the participants as well vels. This polymorphism has also a protective effect on metabolic syndrome susceptibility. Additionally, we described for the first time a rare potentially pathogenic BDNF variant in a Brazilian patient with severe obesity and childhood-onset.
  Diabetes is a global public health threat with a considerably high burden in low- and middle-income countries. The application of self-care practice by people living with diabetes helps to manage diabetes and its complications, and to lengthen their life. However, the level of diabetes self-care practice in Ethiopia is very low.
 
  A cross-sectional study was conducted among people living with type 2 diabetes who were on follow-up from January 01 to 31, 2019 at Yekatit 12 Hospital. A systematic sampling technique was employed to recruit 354 study participants.  https://www.selleckchem.com/products/gdc6036.html  A face-to-face interview was administered by trained data collectors using a structured questionnaire. Diabetes self-care practice was assessed by using Summary of Diabetes Self-Care Activities (SDSCA) scale. Multi-variable binary logistic regression analysis was carried out to identify factors associated with diabetes self-care practice.
 
  More than half (52.0%, 95% CI 49.9% - 57.1%) of the people living with diabetes had poor diabetes self-care practs and educating about the severity of the disease for better management of blood sugar levels and hindrance of complications.
  Iron deficiency anemia (IDA) is a common sequela of inflammatory bowel disease (IBD), arising from the combined effects of gastrointestinal blood loss and reduced iron absorption. Given this, intravenous (IV) iron should be considered as the first-line treatment in patients with clinically active IBD. The present study evaluated the budget impact of administering IV iron with ferric derisomaltose (FDI) versus ferric carboxymaltose (FCM) in patients with IDA and IBD in Norway, Sweden, and Finland.
 
  A cohort level model of iron need was developed using a bivariate distribution of hemoglobin and bodyweight based on observational data from a multi-country Scandinavian study of patients with IDA and IBD. The base case analysis was conducted over 5 years in patients with IDA with mean bodyweight of 75.4 kg (SD 17.5 kg) and hemoglobin levels of 10.77 g/dL (SD 1.43 g/dL). Infusion costs were modeled using diagnosis-related groups. Sensitivity analyses were performed around different patient characteristics, care sts with IDA and IBD. The reduction in infusions was accompanied by substantial cost savings relative to FCM over 5 years across all three Nordic countries evaluated.
  Health Management Information Systems (HMIS) is an information system for health management and planning at district, regional, and national levels. Problems of data collection and processing, poor information use, lack of identifying information required at specific levels, and inadequacy of resources are hindering the implementation of the program.
 
  To assess the implementation status of Health Management Information System (HMIS) in hospitals of South West Shoa Zone, Oromia, Central Ethiopia.
 
  The assessment was conducted in South West Shoa Zone hospitals using a cross-sectional study design. Using three dimensions, namely, availability of resources, compliance to guideline, and utilization of information were studied. All hospitals in the zone were included and 210 health workers were included in the study. Quantitative data were entered into Epi-data and analyzed using SPSS.v.23. Descriptive summery was done using the proportion and frequencies and qualitative results were analyzed thematically. The tation status of HMIS in the study area was poorly implemented according to the preset criteria with stakeholders. Therefore, allocation of budget specifically for HMIS, strengthening capacity building activities such as training and supportive supervision with written feedbacks are recommended for effective implementation of the Health Management Information System.
  Star anise fruits (
  Hook.) have been used as an important treatment in traditional Chinese medicine. The previous studies reported the activity of the non-polar fractions as potential sources of antibacterial metabolites, and little was done concerning the polar fractions of star anise.
 
  The antibacterial activity of the star anise aqueous methanolic (50%) extract against multidrug-resistant 
  AB5057 and methicillin-resistant 
  (MRSA USA300) was investigated in vitro (disc diffusion assay, minimum bactericidal concentration determination, anti-biofilm activity and biofilm detachment activity). The antibacterial activity was further tested in vivo using a murine model of MRSA skin infection. Ultra-performance liquid chromatography coupled to high-resolution mass spectrometry (UPLC/HRMS) approach was applied for the identification of the metabolites responsible for the antibacterial activity. The antioxidant potential was evaluated using five in vitro assays TAC (total antioxidant capacity), DPPH, ABTS, these metabolites and the proposed antibacterial activity.
 This study proposes the potential use of star anise polar fraction in anti-virulence strategies against persistent infections and for the treatment of staphylococcal skin infections as a topical antimicrobial agent. To our knowledge, our research is the first to provide the complete polar metabolome list of star anise in an approach to understand the relationship between the chemistry of these metabolites and the proposed antibacterial activity.