https://www.selleckchem.com/products/xl177a.html This study describes the clinical experience with the use of Easy Bite® light-curing hydrostatic splint for initiating muscle relaxation and determining the therapeutic position of the lower jaw under the control of surface electromyography at the stage of occlusal splinting prior to orthodontic treatment. Surface electromyography was performed using a BTS TMJOINT apparatus from BTS Bioengineering (Italy) and the Dental Contact Analyzer software package. The article describes the interpretation of the six indices, such as POC TA, POC MM, BAR, TORS, IMP, ASIM, for the analysis of occlusion and muscle balance in a clinical example with illustrations. The developed algorithm for determining the therapeutic position of the lower jaw is described and the results of 5 months of occlusal splint therapy of a 12-year-old patient with skeletal grade 2, a vertical type of jaw growth, a skeletal reduction of the lower jaw branch on the right, aseptic necrosis and fragmentation of the articular head of the right TMJ, arthritis-arthrosis of the left TMJ, dysplasia of both TMJs on the background of undifferentiated connective tissue dysplasia are presented.At present, our country continues intensive research to find and introduce into practice new natural medicinal preparations made from ecologically clean endemic plants of Georgia. An example of such studies in the Iveria-Pharma company is the domestic drug Lazolex (extract of the pericarpium of an unripe walnut), which has passed the necessary preclinical tests and began to be used in the clinic as an antiherpetic agent. On healthy volunteers, we found positive immunotropic effects of Lazolex. Therefore, we considered it necessary to study the antiviral effect of the drug and its immunomodulatory properties in a clinical setting, specifically in chronic herpetic stomatitis. First of all, it was shown that the state of the patients' immune system was in a clear correlation with the