Whole flours showed higher antioxidant properties. According to the obtained results, it is possible to allege all approved health claims referred to wheat, since all analyzed samples, especially whole flour and bran fraction, showed potential health benefits, as functional ingredients or functional foods, related with their phytochemical composition.Steel slag, a by-product of steelmaking, imposes lots of negative impacts on the environment. For alleviating negative impacts, more and more experiments have been carried out to explore the application possibility of steel slag. The purpose of this study is to explore the feasibility of steel slag being applied in induction healing asphalt concretes to replace coarse and fine aggregate. Surface texture and pore sizes of steel slag were firstly tested, and then steel slag and basalt asphalt mixtures modified with steel fibers were prepared. Moisture susceptibility, dynamic stability, mechanical property, thermal property, induction heating speed, natural cooling speed and healing property of the asphalt mixtures were evaluated. Results showed that steel slags had more obvious holes in the surface while the surface area is much larger than that of basalt. Furthermore, steel fibers and steel slag both have dynamic stability, and steel fibers contribute to increased moisture resistance while steel slag is not. Steel slag asphalt concrete showed better mechanical property and better capacity to store heating. Steel slag asphalt mixtures had a similar heating speed to basalt asphalt mixtures but a significantly slower cooling rate. Finally, the induction healing test and CT scanning test demonstrated that steel slag asphalt mixtures had a similar healing ability to basalt asphalt mixtures. It can be concluded that steel slags have the potential to replace the natural aggregates to be applied in induction heating self-healing asphalt concretes.BACKGROUND International treatment guidelines for Helicobacter pylori infection recommend a proton pump inhibitor (PPI)/amoxicillin/clarithromycin (CAM) regimen (PAC) or PPI/amoxicillin/metronidazole (MNZ) regimen (PAM) as first-line therapy based on culture and sensitivity testing. As incidence rates of antimicrobial agent-resistant strains are changing year by year, it is important to reevaluate the efficacy of eradication regimens. We performed a meta-analysis to evaluate the efficacy and safety of PAC and PAM based on different locations categorized by the reported incidence of CAM- and MNZ-resistant strains. METHODS Randomized control trials (RCTs) comparing eradication rates between PAC and PAM first-line treatment up to December 2018 were included. We divided RCTs into four groups based on resistance to CAM ( less then 15% or ≥ 15%) and MNZ ( less then 15% or ≥ 15%). RESULTS A total of 27 studies (4825 patients) were included. Overall eradication rates between PAC and PAM were similar (74.8% and 72.5%, relative risk (RR) 1.13, 95% confidence interval (CI) 0.91-1.39, P = 0.27) in the intention-to-treat analysis. In areas with low MNZ- and high CAM-resistance rates, PAM had a significantly higher eradication rate than PAC (92.5% vs. 70.8%, RR 0.29, 95% CI 0.13-0.68). In areas with high MNZ- and low CAM-resistance rates, the eradication rate with PAC was only 72.9%. CONCLUSIONS Overall eradication rates with PAC and PAM were equivalent worldwide. In low MNZ-resistance areas, PAM may be recommended as first-line therapy. However, the efficacy of PAC may be insufficient, irrespective of susceptibility to CAM.Outcomes for pediatric patients with acute myeloid leukemia (AML) remain poor, highlighting the need for improved targeted therapies.  https://www.selleckchem.com/  Building on the success of CD19-directed immune therapy for acute lymphocytic leukemia (ALL), efforts are ongoing to develop similar strategies for AML. Identifying target antigens for AML is challenging because of the high expression overlap in hematopoietic cells and normal tissues. Despite this, CD123 and CD33 antigen targeted therapies, among others, have emerged as promising candidates. In this review we focus on AML-specific T cell engaging bispecific antibodies and chimeric antigen receptor (CAR) T cells. We review antigens being explored for T cell-based immunotherapy in AML, describe the landscape of clinical trials upcoming for bispecific antibodies and CAR T cells, and highlight strategies to overcome additional challenges facing translation of T cell-based immunotherapy for AML.To study the influence of the structural parameters of the ammunition liner of small-caliber ammunition on the forming characteristics of the projectile, an integrated circumferential multiple explosively formed projectile (MEFP) warhead with an integrated shell and the liner was initially designed, and the wall thickness of the liner is variable. LS-DYNA finite-element software is used to simulate the integral circumferential MEFP of the preliminary design, based on the numerical simulation results, the influence of the thickness at the center of the liner, and the curvature radius of the liner on the shape and velocity of the formed projectile. The numerical simulation results show that when the thickness of the center of the liner is constant and the curvature radius increases gradually, the velocity of the formed projectile decreases and the length Diameter ratio of formed projectile decreases gradually. When the curvature radius of the liner remains unchanged, the velocity of the formed projectile decreases with the increase of the thickness of the center of the liner, and the shape of the formed projectile does not change significantly. The results show that when the design of integrating the shell and the liner was adopted for the integral circumferential MEFP warhead, the shape of the formed projectile is greatly affected by the curvature radius of the liner (curvature radius of inner and outer walls of the liner), but less by the thickness of the center of the liner. The velocity of the formed projectile is affected by the curvature radius of the inner and outer walls of the liner and the thickness of the center of the liner. Moreover, the influence of the thickness of the center of the liner on the velocity of the formed projectile is greater than that of the curvature radius of the outer wall of the liner.