Acute pulmonary embolism (PE) is a potentially life-threatening manifestation of venous thromboembolic disease. Severe acute respiratory syndrome-coronavirus-2, a novel coronavirus that causes coronavirus disease-2019 (COVID-19), has been associated with an increased risk of thrombosis. We describe the therapeutic challenges of 3 patients presenting with PE and suspected or confirmed COVID-19. (Level of Difficulty Beginner.).Overwhelming anthropogenic activities lead to deterioration of natural resources and the environment. The microorganisms are considered desirable, due to their suitability for easy genetic manipulation and handling. With the aid of modern biotechnological techniques, the culturable microorganisms have been widely exploited for the benefit of mankind. Metagenomics, a powerful tool to access the abundant biodiversity of the environmental samples including the unculturable microbes, to determine microbial diversity and population structure, their ecological roles and expose novel genes of interest. This review focuses on the microbial adaptations to the adverse environmental conditions, metagenomic techniques employed towards microbial biotechnology. Metagenomic approach helps to understand microbial ecology and to identify useful microbial derivatives like antibiotics, toxins, and enzymes with diverse and enhanced function. It also summarizes the application of metagenomics in clinical diagnosis, improving microbial ecology, therapeutics, xenobiotic degradation and impact on agricultural crops.The ongoing outbreak of the COVID-19 as the current global concern threatens lives of many people around the world. COVID-19 is highly contagious so that it has infected more than 1,848,439 people until April 14, 2020 and killed more than 117,217 people. The main aim of this study is to develop an agent-based model (ABM) that simulates the spatio-temporal outbreak of COVID-19. The main innovation of this research is investigating the impacts of various strategies of school and educational center closures, heeding social distancing, and office closures on controlling the COVID-19 outbreak in Urmia city, Iran. In this research, the outbreak of COVID-19 disease was simulated with the help of ABM so that all agents considered in the ABM along with their attributes and behaviors as well as the environment of the ABM were described. Besides, the transmission of COVID-19 between human agents was simulated based on the SEIRD model, and finally, all control strategies applied in Urmia city along with corresponding actol strategies on controlling the outbreak of disease.
  Sars-CoV2 is a novel coronavirus that is transmitted to humans through zoonosis and characterised by mild to moderate pneumonia-like symptoms. The outbreak began in Wuhan, China, and has now spread on a global scale. Doubling time is the amount of period taken for a particular entity (that tends to grow over time) to double its size/value. This study's prime target is to develop relationships between the variation in the doubling time of the number of cases of COVID-19 virus and various socio-economic factors responsible for them. These frameworks focus on the relationships instead of relational data, so here in graph structures, we have generated different patterns of doubling rates and drawn the inferences.
 
  Only significant countries affected by the COVID-19 virus are studied, and accordingly, collected datasets of growth of cases in the form of spreadsheets. The doubling rate is determined by calculating the doubling time for each day and then plotting these datasets in graphical form.
 
  The doubling ty share the same denominator is the necessity for requisite healthcare systems and medical staff. Still, the shortage of this component does not certainly mean that taking necessary steps would be ineffective. Transmission of COVID-19 to humans by zoonosis reveals that the global community is required to be observant concerning similar pandemics in the future.Smart Factory has already become an irresistible entity in manufacturing, which has led to a much wider scope of existing manufacturing innovations and the achievement of qualitative improvements.  https://www.selleckchem.com/products/bmh-21.html  Unsurpassed progress has been made in the manufacturing sector through the combination of professional know-how and advanced IT, and HACCP has already thoroughly managed all steps from raw materials for agricultural and livestock products to processing, packaging and distribution before digitalization. Sanitary issues in each country have now been raised to the level of national security under the influence of COVID-19. Although HACCP is already well-managed by country, we have looked at this discussion and detailed technological transformation from a digital data perspective, as it is now possible to collect, store, record and report data to government offices more smartly in line with technological advances in smart factories. The intersection of smart factories and HACCPs is consistent in terms of data collection, storage and utilization. Furthermore, the addition of Blockchain technology to strictly prevent data forgery is more interesting. Although the use of Blockchain in general factories has been relatively insignificant, it is expected that the use of Blockchain technology will be expanded through smart HACCP, which forms the interface between smart factory technology and HACCP, and that agricultural, livestock and household factories will introduce more smart factories.In Western countries, such as Australia and the UK, a significantly greater proportion of men (relative to women) are overweight and obese, yet relatively few weight loss interventions have been developed that sufficiently target men. This lack of male-focused programming may be in part because 'traditional' weight loss programs are unappealing for what is considered a 'hard-to-reach' population. One program that appears to have such appeal for men is the MAN v FAT Football (MVFF) program, based out of the United Kingdom, which is designed for men with a body mass index of (or greater than) 27.5. MVFF encourages men's participation in a community-based weight loss program that incentivizes weight loss through participation in a football league, and since 2016 MVFF has supported the weight loss efforts of several thousand men. Using MVFF as an exemplar, our aim was to derive insight into how men experience a male-only competitive, sport-based weight loss program. We recruited twenty-seven players (Mage = 41.13, SD = 9.