https://www.selleckchem.com/products/ve-821.html Purpose Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease in adults with motor disorders. It is the most prevalent neuromuscular disease worldwide. Two forms exist a sporadic form (90% of cases) and a family form due to mutations in more than 20 genes. Patient clinical characteristics are muscle weakness, dysphagia, dysphonia and respiratory failure. The cause of ALS is unknown as we do not know why it affects some people and not others. The aim of this pilot study is to evaluate the possible relationship between dysphonia and dysphagia in ALS patients and if a deterioration of speech ability is linked with a worsening of dysphagia. Materials and methods Between March 2017 and February 2018, 27 newly diagnoses patients (about 2 months) were examined in the ENT Clinic of our University Hospital. The bulbar-onset of ALS was diagnosed by neurologists. Results According to the endoscopic and clinical results, patients were classified in 4 classes of dysphagia. Laryngology and speech pathology assessment with spectroacuostic analysis of speech using Praat software are fundamental for the proper evaluation of dysphonia of these patients. This study was the first attempt to find a vocal indicator of advancement in swallowing dysfunction in the patient population of ALS. Preliminary findings indicate that the reduction in the maximum fundamental frequency is associated with advancement of dysphagia. Conclusions Monitoring the vocal parameters could be useful in order to give an early rehabilitation aid to these patients improving their quality of life and reducing aspiration risks.Background Immune thrombocytopenia (ITP) has been known to be associated with assorted virus infections. This study aims to investigate the Epstein-Barr virus infection status in chronic ITP patients by real-time quantitative polymerase chain reaction. Methods 42 chronic ITP patients and 42 healthy donors were retr