Academic trials or IITs were found to be the major sponsors, with 52% of trials being sponsored by them followed by pharmaceutical companies as a secondary sponsor (38%). Additionally, trials on chemotherapeutic agents constituted 50% of the trials followed by trials on targeted therapy (31%). The review provides insight on the effectiveness of the pharmaceutical industry and identify unmet clinical needs of stakeholders. With accumulated experience of Chinese oncologists and increasing support from the Chinese government, greater success could be anticipated in the near future.
  The Hospital Elder Life Program (HELP) has been shown to prevent delirium in hospitalized older adults. The objective of this study was to test the efficacy of HELP adapted to long-term care (HELP-LTC).
 
  Cluster randomized controlled trial.
 
  A 514-bed academic urban nursing home.
 
  A total of 219 long-term nursing home residents who developed an acute illness or change in condition were randomly assigned to HELP-LTC (n = 105) or usual care (n = 114) by unit.
 
  HELP-LTC is a multicomponent intervention targeting delirium risk factors of cognitive impairment, immobility, dehydration, and malnutrition.  https://www.selleckchem.com/products/elsubrutinib.html  Two certified nursing assistants (CNAs) delivered HELP-LTC components twice daily 7 days per week. In addition, recommendations were given to primary providers to reduce medications associated with delirium.
 
  Delirium (primary outcome) and delirium severity were ascertained each weekday by a research assistant blinded to group assignment, using the Confusion Assessment Method (CAM) and CAM severity score (CAMuch as consistent assignments delivered to both groups, and adaptations of the intervention may have biased results toward null. J Am Geriatr Soc 682329-2335, 2020.
 An intervention targeting delirium risk in long-term nursing home residents did not prevent delirium or reduce delirium symptoms. Baseline differences in cognitive function between groups, greater than expected improvements in both groups, quality-enhancing practices such as consistent assignments delivered to both groups, and adaptations of the intervention may have biased results toward null. J Am Geriatr Soc 682329-2335, 2020.
  Education of family members about infant weaning practices could affect nutrition, growth, and development of children in different settings across the world.
 
  To compare effects of family nutrition educational interventions for infant weaning with conventional management on growth and neurodevelopment in childhood.
 
  We used the standard strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 5), MEDLINE via PubMed (1966 to 26 June 2018), Embase (1980 to 26 June 2018), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to 26 June 2018). We searched clinical trials databases, conference proceedings, and references of retrieved articles. We ran an updated search from 1 January 2018 to 12 December 2019 in the following databases CENTRAL via CRS Web, MEDLINE via Ovid, and CINAHL via EBSCOhost.
 
  We included randomised controlled trials that examined effects of nutrition education for weaning practices delivered to families ofth parameters in the first two years of life affect long-term childhood growth and development. Further studies are needed to resolve this question.
 Nutrition education for families of infants may reduce the risk of undernutrition in term-born infants (evidence of low to moderate certainty due to limitations in study design and substantial heterogeneity of included studies). Modest effects on growth during infancy may not be of clinical significance. However, it is unclear whether these small improvements in growth parameters in the first two years of life affect long-term childhood growth and development. Further studies are needed to resolve this question.Research on visuospatial memory has shown that egocentric (subject-to-object) and allocentric (object-to-object) reference frames are connected to categorical (non-metric) and coordinate (metric) spatial relations, and that motor resources are recruited especially when processing spatial information in peripersonal (within arm reaching) than extrapersonal (outside arm reaching) space. In order to perform our daily-life activities, these spatial components cooperate along a continuum from recognition-related (e.g., recognizing stimuli) to action-related (e.g., reaching stimuli) purposes. Therefore, it is possible that some types of spatial representations rely more on action/motor processes than others. Here, we explored the role of motor resources in the combinations of these visuospatial memory components. A motor interference paradigm was adopted in which participants had their arms bent behind their back or free during a spatial memory task. This task consisted in memorizing triads of objects and then verbally judging what was the object (1) closest to/farthest from the participant (egocentric coordinate); (2) to the right/left of the participant (egocentric categorical); (3) closest to/farthest from a target object (allocentric coordinate); and (4) on the right/left of a target object (allocentric categorical). The triads appeared in participants' peripersonal (Experiment 1) or extrapersonal (Experiment 2) space. The results of Experiment 1 showed that motor interference selectively damaged egocentric-coordinate judgements but not the other spatial combinations. The results of Experiment 2 showed that the interference effect disappeared when the objects were in the extrapersonal space. A third follow-up study using a within-subject design confirmed the overall pattern of results. Our findings provide evidence that motor resources play an important role in the combination of coordinate spatial relations and egocentric representations in peripersonal space.
  To evaluate the management of sporadic vestibular schwannomas (VS) with a 12-year follow-up.
 
  Retrospective study of all VS patients initially treated in 2005 in a tertiary referent center.
 
  Initial decision making for microsurgical resection (MSR) or wait-and-scan (WaS) was according to VS size and hearing; subsequently, MSR or stereotactic radiosurgery (SRS) was proposed dependent on VS growth and size, hearing, and patient's age or willingness.
 
  Two hundred and one sporadic VS were included. The first management apportionment was 120 WaS (61.5%), 72 MSR (37%), three SRS (1.5%), and six others refused MSR and were lost to follow-up (LFU). Within 1 year, 95 (47%) VS were surgically removed; 17 (8.5%) were treated by SRS; and 35 (17.5%) were LFU. The proportions for SRS and LFU were virtually unchanged for the following years, and the proportion under MSR increased slightly within 3 years and then remained stable. Finally, at 12 years, 104 (51.5%) cases had been operated on, 21 (10.5%) treated by SRS, 23 (11.