https://www.selleckchem.com/products/anacetrapib-mk-0859.html 76, 0.147 and 0.109 for each unit increase in environmental regulation of surrounding cities, respectively. In fact, cities with loose regulation become the pollution shelters. The spatial spillover effects offset the improvement effects of local environmental regulations on the air quality. Furthermore, the comparison amongst three urban agglomerations showed that the spatial spillover effects of PM2.5 concentration in BTH and YRD are higher than that of PRD. This is attributed to differences in industrial structure, population density, economic development, FDI and geographical location. Therefore, the spatial spillover effects should be taken into consideration and joint regulation should be strengthened to address air pollution issues in urban aggregations.Woodchip bioreactors are a practical, low-cost technology for reducing nitrate (NO3) loads discharged from agriculture. Traditional methods of quantifying their performance in the field mostly rely on low-frequency, time-based (weekly to monthly sampling interval) or flow-weighted sample collection at the inlet and outlet, creating uncertainty in their performance and design by providing incomplete information on flow and water chemistry. To address this uncertainty, two field bioreactors were monitored in the US and New Zealand using high-frequency, multipoint sampling for in situ monitoring of NO3-N concentrations. High-frequency monitoring (sub hourly interval) at the inlet and outlet of both bioreactors revealed significant variability in volumetric removal rates and percent reduction, with percent reduction varying by up to 25 percentage points within a single flow event. Time series of inlet and outlet NO3 showed significant lag in peak concentrations of 1-3 days due to high hydraulic residence time, where calculations from instantaneous measurements produced erroneous estimates of performance and misleading relationships between residence tim