Timely detection and treatment are important for the control of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis. The objective of this study was to measure the performance of the Visby Medical Sexual Health Test, a single-use, point-of-care PCR device.
 
  Women aged 14 years and older who presented consecutively to ten clinical sites across seven US states were enrolled for a cross-sectional, single-visit study. Patients who consented to participate, and who had not used any exclusionary products in the genital area in the previous 48 h, provided self-collected vaginal swabs for testing with the investigational device. Untrained operators received the specimens and ran the device using the guide provided. Specimens had to be run within 2 h of collection to be considered valid. For comparison, patient-infected status was derived by testing clinician-collected vaginal specimens with the Hologic Aptima Combo 2 Assay and Aptima Trichomonas vaginalis Assay, as well as the BD ProbeTec CT/GC vaginalis (n=1449).
 
  This innovative, rapid, easy-to-use, single-use, point-of-care device to detect C trachomatis, N gonorrhoeae, and T vaginalis infections showed excellent sensitivity and specificity, and could represent an important advance in the development of rapid diagnostics for sexually transmitted infections and other infectious diseases.
 
  Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases.
 Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases.
  To examine the association between preschool-aged children's exposure to adverse childhood experiences (ACEs) and multiple, intersecting domains of school readiness using a nationally representative sample.
 
  A sample of 15 402 preschool-aged children (3-5years) in the US from the 3 most recent cohorts (2016-2018) of the National Survey of Children's Health were employed. Primary caregivers were asked survey questions about the adversities experienced by focal children. Four distinct domains of school readiness among the children were also derived from the survey early learning skills, self-regulation, social-emotional development, and physical health and motor development.
 
  Although nearly one-half of children who had not been exposed to ACEs were on-track across all domains, only 1 in 5 children exposed to 3 or more ACEs were on-track across all domains. Follow-up analyses identified parenting stress and reduced positive parenting practices as significant mediators of this association. Multivariate results also indicated that, regardless of the school readiness domain examined, an accumulation of ACEs increased the rate of items on which a child needs support or is at-risk.
 
  An accumulation of ACEs among preschool-aged children elevates risk within and across school readiness domains. These findings highlight the urgent need to identify best practices to reduce ACE exposure, as well as improve school readiness during early childhood.
 An accumulation of ACEs among preschool-aged children elevates risk within and across school readiness domains. These findings highlight the urgent need to identify best practices to reduce ACE exposure, as well as improve school readiness during early childhood.
  To assess whether early modifiable dietary factors and obesity measures are associated with leukocyte telomere length at 3-5years of age after controlling for the heritability of leukocyte telomere length in a prospective cohort of low-income Latina mothers and their children in San Francisco.
 
  We analyzed data from the Latinx, Eating and Diabetes cohort, a prospective study of 97 woman-infant dyads. We used linear regression models to evaluate associations between early dietary factors and obesity measures and child leukocyte telomere length at 3-5years of age. Multivariable models included child age at the time of telomere collection, breastfeeding at 6months (yes/no), obesity at 6months, maternal education, child sex, and maternal and paternal leukocyte telomere length.
 
  Data for 73 of the 97 children at 3-5years of age were analyzed. Any breastfeeding at 6months was positively associated (β=0.14; P=.02) and obesity at 6months was negatively associated (β=-0.21; P<.001) with leukocyte telomere lengtllular health than obesity later in childhood.The circadian clock is a complex cellular mechanism that controls a series of physiological processes, including inflammation. It can directly interact physically with the components of the key inflammatory pathway. Similarly, inflammation can also lead to circadian rhythm disorders, which may further amplify the inflammatory response and aggravate tissue damage. This review offers a structured overview that focusses on the core proteins of the circadian clock and their interactions with inflammatory players, and provides a potential mechanism for the pathological rhythms observed under inflammatory conditions.
  Eponyms are commonly used in medicine, but there are no specific studies of the use of eponyms in clinical chemistry.
 
  Clinical chemistry eponyms were manually collected from books, review articles and journal articles from 1847 through 2020.  https://www.selleckchem.com/products/Chlorogenic-acid.html  Eponym usage was examined by searching titles and abstracts in PubMed. Custom Python scripts were used to first permute eponyms into multiple forms, and then to search PubMed using Biopython. The eponyms identified in PubMed were further focused on 2 clinical chemistry journals Clinica Chimica Acta [CCA] and Clinical Chemistry [CCJ].
 
  The manual collection identified >300 eponyms in clinical chemistry. The Biopython search of PubMed identified a subset of 97 unique eponyms in 33,232 articles. PubMed identified 26 eponyms used in 130 CCA articles; whereas a full-text search identified 1187 articles. In comparison, PubMed identified 36 eponyms used in 158 CCJ articles; whereas a full-text CCJ search identified 708 articles. PubMed shows that the journals CCA and CCJ had a peak number of eponym citations in 1977 followed by a steady decline.
 
  Eponyms have been frequently used in clinical chemistry with 97 eponyms in common use in PubMed. Overall, the use of clinical chemistry eponyms appears to be declining.
 Eponyms have been frequently used in clinical chemistry with 97 eponyms in common use in PubMed. Overall, the use of clinical chemistry eponyms appears to be declining.