Results ICCs (1, 3) of the data obtained by OpenPose and VICON were almost perfect. There were significant associations between the data obtained by OpenPose and VICON. ICCs (2, 1) between the data obtained by OpenPose and VICON were almost perfect or substantial for trunk, knee and ankle joints, and fair on the hip joint. There were fixed biases on knee and ankle joints, and proportional biases on trunk and hip joint. Significance OpenPose based motion analysis is reliable and has the advantage of being low cost and easier to operate than conventional methods. In future, to consider the clinical utility of OpenPose, it is necessary to identify the error between the true values indicating actual joint movement and data obtained by OpenPose with its correction for fixed and proportional biases. (295 words).Introduction Falls are associated with numerous risk factors, such as motor and cognitive impairments. However, the neural correlates of falls are poorly understood. Objectives Here, we aimed to assess patterns of structural, and resting-state functional connectivity (FC) alterations related to falls in a group of older adults with a history of falls compared to non-fallers.  https://www.selleckchem.com/Androgen-Receptor.html  Methods Fourteen elderly fallers (mean age = 78.1 ± 1.5 yrs, >2 falls previous six months), and 20 healthy controls (mean age = 69.6 ± 1.3 yrs) were examined. All participants underwent a 3T MRI scan obtaining 3D T1-weighted images, and eyes-open resting-state (rs)-fMRI. Voxel-based morphometry was conducted to detect grey matter differences between the groups. Independent component analysis was conducted based on rs-fMRI and number of attention-and-motor related functional networks was identified and compared between groups using an independent-sample T-test. Results No differences were observed in grey matter between the groups after correcting for age and gender (p > 0.01, FWEc). Compared with non-fallers, the fallers had lower FC in cerebellar, frontal and parietal cortical nodes within the sensorimotor network (SMN), lateral motor network (M1), Cerebellar network (CBL), frontal-striatal network (FSN), executive control network (ECN), and dorsal attention network (DAN). Moreover, fallers had increased FC in the basal ganglia network (BGN), Left paracentral in M1 and SMN, and right hippocampus in DAN (p less then 0.01, FWEc). Conclusions Among fallers, reduced connectivity was observed in areas that relate to integration of information, while increased connectivity was found in areas associated with motor and sensory information processing. Together, these results provide evidence to the complex multidimensionality of the neural underpinnings of falls. Furthermore, these findings may help emphasize the importance of interventions that target both motor and cognitive aspects.Background Percutaneous osseointegrated (OI) docking of prosthetic limbs returns loading directly to the residual bone of individuals with amputations. Lower limb diaphyseal biomechanics have not been studied during the wide range of daily activities performed by individuals with lower extremity amputations; therefore, little is known about the loads experienced at the bone-endoprosthetic interface of a percutaneous OI device. Research question Does residual limb length and/or gender influence loading magnitudes in the diaphysis of the femur or tibia during daily activities? Methods This observational study used motion capture data from 40 non-amputee volunteers performing nine activities ranging from low to high demand, to virtually simulate residual limbs of amputees. To simulate diaphyseal bone loading in individuals with lower limb amputations, virtual joints were defined during post-processing at 25, 50, and 75 % of residual limb length of both the femur and the tibia, representing six clinically relevanion of percutaneous OI patients.Background The purpose of this prospective study was to understand the relation between gait outcomes and patient satisfaction one year after total knee arthroplasty (TKA). Methods Seventy-nine patients were evaluated before and one year after TKA using clinical gait analysis. Specific gait outcomes were analyzed gait speed, stance phase, range of motion (ROM) knee flexion and maximal knee flexion. The parameters of interest selected for the statistical analysis were gait speed and maximal knee flexion during gait. The Western Ontario and MacMaster Osteoarthritis Index (WOMAC) and patient satisfaction were also assessed. The satisfaction was evaluated using a questionnaire and was splited in five categories very unsatisfied, unsatisfied, neutral, satisfied or very satisfied. To assess associations between patient satisfaction and maximal knee flexion during gait and gait speed, an unadjusted ordinal logistic regression analysis was used. The analysis was then adjusted for covariates age and Body Mass Index (BMI) before surgery and WOMAC pain one year after surgery. Results All gait outcomes after TKA had significantly improved. The ordinal logistic regression analysis found significant associations between patient satisfaction and maximal knee flexion after TKA (unadjusted and adjusted) but not for gait speed. Conclusion These findings show that all patients improved their gait outcomes one year after TKA but only a higher maximal knee flexion during gait may influence the level of patient satisfaction.Background Pain and proprioception deficits are often associated with knee pathologies and resultant quadriceps muscle inhibition. There is a need for new approaches to mitigate active knee pain and restore muscle function during walking. Activating properties of the somatosensory system with common pain and sensory pathways offers a novel opportunity to enhance quadriceps function during walking. Research question Conduct a controlled clinical trial that investigates the effects of applying intermittent vibrational cutaneous stimulation during walking on knee pain and symptoms and their correlations to gait parameters. Methods This longitudinal controlled cross-over clinical study included thirty-two patients randomly and blindly assigned to active Treatment A and passive Treatment B for 4 weeks with a 2-week washout period between treatments. Results Subjects when wearing active Treatment A for 4 weeks had significant (p = 0.04) improvement in patient reported outcomes, while they had no significant differences with passive Treatment B (p > 0.