https://www.selleckchem.com/products/blasticidin-s-hcl.html We read with great interest the article by Laure et al (1) where the authors investigated the accuracy of liver stiffness measurement (TE-LSM) in distinguishing porto-sinusoidal vascular liver disease (PSVD) from cirrhosis in patients with signs of portal hypertension (PH). The author's conclusions demonstrated that when TE-LSM 20 kPa, the possibility of considering PSVD is very unlikely. After reading this article carefully, we think the following concerns need to be pointed out. Paranoia manifests similarly in subclinical and clinical populations and is related to distress and impairment. Previous work links paranoia to amygdala hyperactivity and reduced activation of the ventrolateral prefrontal cortex (VLPFC), a region thought to regulate amygdala activity. This study aimed to reduce subclinical paranoia in 40 undergraduates by increasing activity of the VLPFC via single-session transcranial Direct Current Stimulation (tDCS). A double-blind, crossover (active vs. sham stimulation) design was used. Paranoia significantly decreased after active stimulation (d =0.51) but not sham (d =0.19), suggesting that tDCS of VLPFC was associated with mean-level reductions in paranoia. These findings demonstrate preliminary support for the role of single-session active stimulation to the VLPFC for reducing subclinical paranoia in healthy individuals. In both clinical and subclinical populations, paranoia is related to distress and poorer functional outcomes. Paranoia has been linkededuced self-reported paranoia in healthy undergraduate students. tDCS may be a promising intervention for reducing paranoia in subclinical and clinical populations. Effects were relatively small and require replication with larger subclinical samples and with clinical samples.Medical writers may make major contributions to the preparation of a manuscript, but are not listed as authors. We assessed the prevalence, affiliation and role of med