https://www.selleckchem.com/mTOR.html erformed in neurosurgery practice. The load of emergency neurosurgery procedures did not change throughout the three periods, which reflects the need to designate ample resources to cover emergencies. Notably, with strict screening for COVID -19 infections, neurosurgical procedures could be safely performed during the early pandemic phase. We recommend to restart performing neurosurgical procedures once the pandemic gets stabilized to avoid possible post pandemic health-care system intolerable overload. The performance of cervical disc arthroplasty (CDA) in the spine with malalignment was unclear. The purpose of the study was to report the clinical and radiological outcomes of single-level CDA in the patients with preoperative reversible kyphosis (RK) and compare these results with a matched cohort of preoperative lordosis. From 2014 to 2018, 36 patients with preoperative RK were matched with 229 patients with preoperative lordosis. The Japanese Orthopedic Association score, Neck Disability Index, Visual Analog Scale were used to evaluate clinical outcomes. Radiological evaluations included range of motion (ROM), C2-7 Cobb angle, shell angle (SA) at surgical level, functional spinal unit (FSU) angle and heterotopic ossification (HO). The mean follow-up was 40.1 months. Both groups achieved significant improvements in clinical outcomes without significant intergroup differences. Before surgery, lordosis group had significantly greater C2-7 angle (9.5° vs -8.4°), SA (1.6° vs -3.7°), and FSU (2.9° vs -3.7ry and comparable clinical outcomes after CDA. Despite the remarkable improvements compared with preoperative values, the cervical alignment of RK group was still significantly inferior to that of lordosis group. More HO formation occurred in RK group. Based on these results, we did not recommend CDA to the patients with preoperative RK. There is no dedicated study on outcome after meningioma surgery in neurofibromatosis type 2 (NF