rowing area of interest for speech-language pathologists.
  The aim of this study was to examine the psychometric properties of the culturally adapted Turkish version of the L'Insalata Shoulder Rating Questionnaire (TrLSRQ).
 
  Comprehensibility and content validity of the TrLSRQ were tested on 14 patients and seven physiotherapists, respectively. Subsequently, 90 volunteer patients with shoulder pain completed the TrLSRQ twice within a week for test-retest analysis. Correlations with Shoulder Pain and Disability Index (SPADI), Oxford Shoulder Score (OSS), Penn Shoulder Score (PSS), and Upper Extremity Functional Index (UEFI) were used to assess convergent validity; and pain intensity and active range of shoulder motions were measured to assess criterion validity.
 
  Content validity index of the TrLSRQ was 0.99. The internal consistency was high (Cronbach's 
   = 0.89); and item-total correlations were 0.37-0.74. In test-retest analysis, ICC values were 0.65-0.95 for all items; and 0.86-0.94 for the subcategories. The TrLSRQ scores were positively correlated with UEFId research purposes to evaluate symptoms and functional status of patients with shoulder pain.Purpose The aim of this study was to determine how the speech disorder profiles in Down syndrome (DS) relate to reduced intelligibility, atypical overall quality, and impairments in the subsystems of speech production (phonation, articulation, resonance, and prosody). Method Auditory-perceptual ratings of intelligibility, overall quality, and features associated with the subsystems of speech production were obtained from recordings of 79 children and adults with DS. Ratings were made for sustained vowels (62 of 79 speakers) and short sentences (79 speakers). The data were analyzed to determine the severity of the affected features in each speaking task and to detect patterns in the group data by means of principal components analysis. Results Reduced intelligibility was noted in 90% of the speakers, and atypical overall speech quality was noted in 100%. Affected speech features were distributed across the speech production subsystems. Principal components analysis revealed four components each for the vowel and sentence tasks, showing that individuals with DS are not homogeneous in the features of their speech disorder. Discussion The speech disorder in DS is complex in its perceptual features and reflects impairments across the subsystems of speech production, but the pattern is not uniform across individuals, indicating that attention must be given to individual variation in designing treatments.Purpose This study explored the neural marker indexing deficits in discriminating lexical tone changes in Mandarin-speaking children with developmental language disorders (DLDs) using mismatch negativity, an event-related potential component for auditory change detection. Mandarin has four lexical tones characterized by a high-level tone (T1), high-rising tone (T2), low-dipping tone (T3), and high-falling tone (T4), in which the T2/T3 contrast is acoustically less discriminable in developmental groups. Therefore, this study further examined how deficits in children with DLD would vary with tonal contrasts' acoustic saliency. Method Event-related potentials were measured using the multideviant oddball paradigm described by Lee et al. (2012), who used Mandarin syllables [i] in T3 as the standard sound (80%), T1 as the large deviant (10%), and T2 as the small deviant (10%). Twelve children with DLD aged between 4 and 6 years participated in this study, and 12 age-matched children with typical development were selected from the data set of Lee et al. (2012) as the controls. Results The T1/T3 change elicited adultlike mismatch negativity in both the DLD and control groups, while no group difference was revealed. The T2/T3 change elicited a robust positive mismatch response (P-MMR) in children with DLD, while the P-MMR was less significant in the control group.  https://www.selleckchem.com/products/bos172722.html  The group comparisons revealed a larger P-MMR in children with DLD than in the control group. Furthermore, children with lower scores in language assessments tend to reveal larger P-MMRs. Conclusions This study demonstrated that deficits in children with DLD in discriminating subtle lexical tone changes reflect greater positivity of P-MMR to T2/T3 change. This implies that MMR to T2/T3 may serve as a neural marker for evaluating language delay in preschoolers.Selection of an appropriate formulation to stabilize therapeutic proteins against aggregation is one of the most challenging tasks in early-stage drug product development. The amount of aggregates is more difficult to quantify in the case of peptides due to their small molecular size. Here, we investigated the suitability of diffusion self-interaction parameters (kD) and osmotic second virial coefficients (B22) for high-throughput (HT) screening of peptide formulations regarding their aggregation risk. These parameters were compared to the effect of thermal stress on colloidal stability. The formulation matrix comprised six buffering systems at two selected pH values, four tonicity agents, and a common preservative. The results revealed that electrostatic interactions are the main driver to control colloidal stability. Preferred formulations consisted of acetate and succinate buffer at pH 4.5 combined with glycerol or mannitol and optional m-cresol. kD proved to be a suitable surrogate for B22 as an indicator of high colloidal stability in the case of peptides as was previously described for globular proteins and antibodies. Formulation assessment solely based on kD obtained by HT methods offers important insights into the optimization of colloidal stability during the early development of peptide-based liquid formulations and can be performed with a limited amount of peptide (∼360 mg).Langmuir monolayers consisting of mixtures of 1-hexadecanol (HD) and 1,2-dipalmitoyl-3-trimethylammonium-propane (DPTAP) (having quaternary amine headgroup) at different molar ratios were prepared to investigate the effect of the surface charge density on the structure of an electric double layer. The fatty alcohol molecules worked as passive spacers to widen the distance between the amine groups in the monolayer, to vary the surface charge density of the monolayer, and these mixture monolayer systems were probed by surface-sensitive sum-frequency vibrational spectroscopy. A strong sum-frequency signal in the OH range for a pure DPTAP monolayer (with a surface charge density of ∼0.4 C/m2) hardly decreased as the surface charge density was reduced up to ∼0.12 C/m2 (1 e per 140 Å2) and afterward decreased monotonically as more HD occupied the monolayer. The Gouy-Chapman theory incorporating a charged-condensed layer in which the counterion concentration is limited by a close packing of the counterions could account for the above saturation behavior in the sum-frequency spectra.