https://www.selleckchem.com/products/cathepsin-Inhibitor-1.html In the late 2019, a report from China was published stating a disease with unknown cause. After that,the outbreak of the COVID-19 caused a pandemic in the world. On March 11, 2020, the outbreak of this virus was reported in 100 countries. The virus is currently spreading rapidly around the world.In the past, coronaviruses caused life-threatening diseases such as SARS and MERSsome areas.Although there is still a debate about the origin of this new coronavirus, it is most likely linked with some animals including bats, civet and pangolin. In this review, we try to simply describe the features of the new coronavirusas well as the recent diagnostic and therapeutic findings.Fungi are recognized as key pathogens in immunocompromised patients. The invasive infection always remains a problem for clinician due to high morbidity and mortality. The treatments of fungal infections are hampered by conventional drugs which are associated with resistance. Drug resistance has become an important problem in a variety of infectious diseases. The rise in the incidence of fungal infections and drug resistance has intensified the need for alternate therapies that affect a new target. This new target must be a growth essential gene product like stress pathway. It has been found that stress pathways can be a potential target in opportunistic fungal infection which played important role in virulence of pathogens. It was helpful in protection from host defense, normal fungal growth and antifungal drug resistance. The disruption of pathway using alternative strategies (chemosensitization and photo-dynamics therapy) can be a novel approach in fighting fungal infections and for drug design.Microbial resistance to conventional therapeutics has become a significant threat to human society. Biofilms serve as the major virulence factor for the microorganisms by resisting the antibiotics and host innate immune system. Antimicrobial pep