Citations counts were found to be borderline significant for RCT (p=0.04) and non-significant for non-RCT.
 
  Visual abstracts might not be effective in disseminating scientific research. We should look at other innovative ways to improve the visibility of the research.
 Visual abstracts might not be effective in disseminating scientific research.  https://www.selleckchem.com/products/ozanimod-rpc1063.html  We should look at other innovative ways to improve the visibility of the research.It was a pleasure to read the article "NOMENs Land The Place of Eponyms in the Anatomy Classroom" published in Anatomical Sciences Education by McNulty et al. (2021). As a senior medical student, I especially took interest in their thoughts of how eponyms impact student learning. I write this to share my experience of learning eponyms in the anatomy classroom as a learner, in response to their conclusion of furthering this discussion.
  Coagulation factor XI (FXI) contributes to the development of thrombosis but appears to play a minor role in hemostasis and is, therefore, an attractive anticoagulant drug target.
 
  To evaluate the safety, pharmacokinetic and pharmacodynamic properties of BAY2433334, an orally administered small molecule targeting activated FXI (FXIa), in healthy men.
 
  This phase 1 study was conducted in two parts. In part 1, 70 volunteers were randomized 41 to receive a single oral dose of BAY2433334 (5-150 mg as oral solution or immediate-release tablets) or placebo. In part 2, 16 volunteers received a single oral dose of five BAY2433334 5 mg tablets with or without a high-calorie breakfast in a randomized crossover study design. Adverse events, pharmacokinetic parameters and pharmacodynamic parameters were assessed up to 72 hours after drug administration. Volunteers were followed up after 7-14 days.
 
  BAY2433334 demonstrated favorable safety and tolerability with a dose-dependent increase in exposure and a terminal half-life of 14.2-17.4 hours. A high-calorie breakfast reduced mean maximum plasma concentration and exposure by 31% and 12.4%, respectively. BAY2433334 was associated with a dose-dependent inhibition of FXIa activity and an increase in activated partial thromboplastin time. Bleeding times in volunteers who had received BAY2433334 were similar to those in volunteers who had received placebo.
 
  These data indicate that BAY2433334 is a promising development candidate for once-daily oral anticoagulation; it is being evaluated in phase 2 dose-finding studies in patients at risk of thrombosis.
 These data indicate that BAY 2433334 is a promising development candidate for once-daily oral anticoagulation; it is being evaluated in phase 2 dose-finding studies in patients at risk of thrombosis.The aim of the study was to explore the effect of acupuncture combined with rehabilitation on cognitive and motor functions in poststroke patients. All patients were divided into Group A and Group B based on different interventions (Group A acupuncture + conventional rehabilitation, Group B conventional rehabilitation alone). Acupuncture was conducted once a day, five times a week for 8 weeks, and rehabilitation (including physical therapy and occupational therapy) was conducted for 2 hr per session, once a day, five times a week for 8 weeks. Mini-mental State Examination (MMSE) and Fugl-Meyer Assessment (FMA) were used to assess the motor and cognitive functions at baseline and the end of 8 weeks. After the intervention, FMA and MMSE scores were improved significantly in the two groups (p less then .05), compared with the scores prior to intervention. After 8 weeks of intervention, a statistically significant difference in the FMA and MMSE scores was observed between the Group A and the Group B. The results suggested that the combined intervention is more effective than the conventional rehabilitation alone in improving cognitive and motor functions in poststroke patients.The purpose of the present study was to examine the acute changes in muscle swelling (as assessed by muscle thickness and echo intensity) and muscle blood flow associated with an acute bout of low-load blood flow restriction (LLBFR) and low-load non-blood flow restriction (LL) exercise. Twenty women (mean ± SD; 22 ± 2years) volunteered to perform an acute exercise bout that consisted of 75 (1 × 30, 3 × 15) isokinetic, reciprocal, concentric-only, submaximal (30% of peak torque), forearm flexion and extension muscle actions. Pretest, immediately after (posttest), and 5-min after (recovery) completing the 75 repetitions, muscle thickness and echo intensity were assessed from the biceps brachii and triceps brachii muscles and muscle blood flow was assessed from the brachial artery. There were no between group differences for any of the dependent variables, but there were significant simple and main effects for muscle and time. Biceps and triceps brachii muscle thickness increased from pretest (2.13 ± 0.39 cm and 1.88 ± 0.40 cm, respectively) to posttest (2.58 ± 0.49 cm and 2.17 ± 0.43 cm, respectively) for both muscles and remained elevated for the biceps brachii (2.53 ± 0.43 cm), but partially returned to pretest levels for the triceps brachii (2.06 ± 0.41 cm). Echo intensity and muscle blood flow increased from pretest (98.0 ± 13.6 Au and 94.5 ± 31.6 ml min-1 , respectively) to posttest (109.2 ± 16.9 Au and 312.2 ± 106.5 ml min-1 , respectively) and pretest to recovery (110.1 ± 18.3 Au and 206.7 ± 92.9 ml min-1 , respectively) and remained elevated for echo intensity, but partially returned to pretest levels for muscle blood flow. The findings of the present study indicated that LLBFR and LL elicited comparable acute responses as a result of reciprocal, concentric-only, forearm flexion and extension muscle actions.
  Weight loss is a primary manifestation of dementia. This review aimed to systematically synthesise the literature on total energy expenditure (TEE) in people with dementia.
 
  The protocol, registered with PROSPERO, was reported against PRISMA guidelines. Eligible studies investigated TEE in people with dementia. Six electronic databases and a supplementary Internet search identified relevant publications. Results were synthesised narratively.
 
  The final library considered the TEE of 358 participants. Two studies used the gold standard method of doubly labelled water (DLW); other studies used TEE measures validated against DLW. TEE varied considerably, from 6095±1353kJ to 9765±2066kJ. The TEE of community-dwelling people with dementia (range 8430±2250kJ-9765±2066kJ) was higher than in institutionalised groups (range 6095±1353kJ-7619±1827kJ).
 
  New technologies will enable future research in this patient population to be less burdensome than those reliant on DLW measures. In planning future research, avoidance of selection bias and considering disease stage and movement are important considerations.