Inhibition of LXRα by GSK2033 or activation of the Wnt/β-catenin pathway by Wnt agonist 1 impaired the effect of XEDAR overexpression on differentiation of MKN45 cells. Moreover, inhibition of RELA mediated by siRNA could promote cell proliferation/migration and rescue the effect of XEDAR overexpression on cell behaviors and expression of genes. Subsequently, overexpression of XEDAR suppressed the growth of GC cells in vivo. Taken together, our findings showed that XEDAR could promote differentiation and suppress proliferation and invasion of GC cells.Childhood maltreatment (CM) and insecure attachment styles may partly explain grief severity following romantic breakup.  https://www.selleckchem.com/products/g150.html  Empirical studies examining the factors that could possibly explain this association, however, remain sparse. The present study tested whether the relations among CM, attachment styles, and romantic breakup grief severity could be explained by emotional suppression in Iranian college students. In a cross-sectional study, 239 Iranian college students (ages 18-45; M = 24.11, SD = 15.29; 50.6% women) with a recent romantic breakup experience were recruited from University of Tabriz. Participants completed a diagnostic interview and self-report battery, including the Persian version of the Child Abuse Self-Reported Scale, Revised Adult Attachment Scale, Romantic Breakup Grief Inventory, and Weinberger Adjustment Inventory. Structural equation modeling was used to empirically explore the relations among variables. Results indicated that those who reported higher levels of CM also reported higher levels of romantic breakup grief. Attachment closeness showed a significant negative and direct effect on romantic breakup grief severity. However, attachment anxiety was positively associated with greater levels of romantic breakup grief. Bootstrapping results showed that CM might affect romantic breakup grief severity via emotional suppression. Furthermore, attachment closeness and attachment anxiety exerted indirect effects on romantic breakup grief severity through emotional suppression. Clinical and empirical implications are discussed.Background Because 24-hour urine collections are cumbersome, many studies have evaluated the use of spot urine samples as a substitute, mostly finding poor concordance between the two. Daily variation in stone parameters probably contributes to the lack of concordance, but specific variation in various stone parameters is not well delineated. The variations likely lead to peaks and troughs, which can increase the risk of stone formation. Methods We prospectively recruited 20 nonstone-forming patients, recording their total fluid intake over 24 hours and collecting voids at first morning, 9 to 10 A.M., 1 to 2 P.M., and 4 to 5 P.M. for evaluation of pH, specific gravity, calcium, citrate, and creatinine. Participants were then asked to double their fluid intake and take a daily True Lemon supplement over the course of the next 3 days. Urine was recollected postintervention. Results Baseline [citrate]/[creatinine] increased throughout the day such that the 5 P.M. level was significantly higher compared with firsr clinical monitoring.Children's speech acquisition is influenced by universal and language-specific forces. Some speech error patterns (or phonological processes) in children's speech are observed in many languages, but the same error pattern may have different effects in different languages. We aimed to explore phonological effects of the same speech error patterns across different languages, target audiences and discourse modes, using a novel method for large-scale corpus investigation. As an additional aim, we investigated the face validity of five different phonological effect measures by relating them to subjective ratings of assumed effects on intelligibility, as provided by practicing speech-language pathologists. Six frequently attested speech error patterns were simulated in authentic corpus data backing, fronting, stopping, /r/-weakening, cluster reduction and weak syllable deletion-each simulation resulting in a "misarticulated" version of the original corpus. Phonological effects were quantified using five separate metrics of phonological complexity and distance from expected target forms. Using Swedish child-speech data as a reference, phonological effects were compared between this reference and a) child speech in Norwegian and English, and b) data representing different modes of discourse (spoken/written) and target audiences (adults/children) in Swedish. Of the speech error patterns, backing-the one atypical pattern of those included-was found to cause the most detrimental effects, across languages as well as across modes and speaker ages. However, none of the measures reflects intuitive rankings as provided by clinicians regarding effects on intelligibility, thus corroborating earlier reports that phonological competence is not translatable into levels of intelligibility.Impelled by a desire to control, suppress, and deny emotional response, stoic individuals may act out their pent-up emotions on relational partners by provoking conflict and/or engaging in partner-directed violent and aggressive behaviors. However, little is known regarding what factors can push stoics over the edge from remaining quiet or avoiding revealing frustrations to initiating aggressive behavior. This relationship between stoicism and aggression is important to consider in serial arguments, where the repetitive nature of a conflict may become increasingly difficult for stoics to manage internally. Here, we examined the influence of stoicism on verbal aggression in serial arguments between romantic partners. We additionally considered the effects of power, perceived resolvability, and argument frequency on the relationship between stoicism and verbal aggression. Using a survey design with a sample of 281 individuals involved in a romantic relationship, we observed that stoicism is positively associated with verbal aggression in serial arguments. While perceived power and resolvability did not moderate the relationship between stoicism and verbal aggression, argument frequency about a serial argument topic was a significant moderator. The results of this study imply that stoicism plays an important role in explaining aggressive tactics in conflict. A high argument frequency about a conflict topic may lead to a buildup of unexpressed emotions, particularly anger, in stoic individuals, resulting in an explosive release of violence and aggression toward a romantic partner. Unique results on the relationship between stoicism and power and directions for future research are discussed.