https://www.selleckchem.com/products/mln2480.html While the intrinsic complexity of natural productbased drug discoveries requires highly integrated interdisciplinary approaches, scientific and technological advances and research trends clearly show that natural products will be among the most important new drug sources in the future. In this review, an overview of the studies conducted for the discovery of multitargeted drug molecules in the rational treatment of gynecological cancers is presented. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Cancer is the leading cause of death worldwide and current mode of cancer treatment causes side effects on normal cells and are still the key challenges in cancer treatment. However, natural products or active compound of medicinal plants are being safe, affordable, and effective in diseases cure. METHODS In this context, scientific studies evidence the health promoting effects of natural products, which work through its anti-oxidant, anti-inflammatory and anti-cancer activity. Thymoquinone (TM), a predominant active compound of Nigella sativa, has confirmed antineoplastic activity through its ability to regulate various genetic pathways. In addition, thymoquinone has established anti-cancerous effects through killing of various cancerous cells, inhibit the initiation, migration, invasion and progression of the cancer. The anti-cancer effects of TM are chiefly mediated via regulating various cell signaling pathways such as VEGF, bcl2/bax ratio, p53, NF-kB and oncogenes. RESULTS The anti-cancer drugs have limitations in efficacy and also causes adverse side effects on normal cells. The combination of anti-cancer drugs and thymoquinone improve the efficacy of drugs as evidences by decrease resistance to drugs and regulating various cell signaling pathways. Moreover, combination of anti-cancer drugs as well as thymoquinone shows synergistic effect on killing of cancer