https://www.selleckchem.com/products/orforglipron-ly3502970.html Metals underpin essential functions in modern society, yet their production currently intensifies climate change. This paper develops global targets for metal flows, stocks, and use intensity in the global economy out to 2100. These targets are consistent with emissions pathways to achieve a 2 °C climate goal and cover six major metals (iron, aluminum, copper, zinc, lead, and nickel). Results indicate that despite advances in low-carbon metal production, a transformative system change to meet the society's needs with less metal is required to remain within a 2 °C pathway. Globally, demand for goods and services over the 21st century needs to be met with approximately 7 t/capita of metal stock-roughly half the current level in high-income countries. This systemic change will require a peak in global metal production by 2030 and deep decoupling of economic growth from both metal flows and stocks. Importantly, the identified science-based targets are theoretically achievable through such measures as efficient design, more intensive use, and longer product lifetime, but immediate action is crucial before middle- and low-income countries complete full-scale urbanization.Understanding the chemistry at twin boundaries (TB) is a well-recognized challenge, which could enable the capabilities to manipulate the functional properties in complex oxides. The study of this atomic imperfection becomes even more important, as the presence of twin boundaries has been widely observed in materials, regardless of the dimensionalities, due to the complexities in growth methods. In the present study, we provide atomic-scale insights into a ∑3(111̅) ⟨11̅0⟩ twin boundary present in pyrochlore-structured Gd2Ti2O7 using atomic-resolution electron microscopy and atomistic modeling. The formation of the observed TB occurs along (111̅) with a 71° angle between two symmetrically arranged crystals. We observe distortions (∼3 to 5% st