https://www.selleckchem.com/products/Fludarabine(Fludara).html The Egger's test was applied for publication bias. A total of 770 COPD participants from 11 trials that met the inclusion criteria were included. The meta-analysis showed that modified SBS could improve the exercise endurance, life quality scores of stable COPD patients, and also showed the potential benefits to pulmonary function of COPD patients than original SBS. The methodological quality of included trials may limit the conclusions that indicate that modified SBS may have a promising treatment for improving FEV /FVC and MVV, increasing exercise endurance and life quality scores on stable COPD patients. The methodological quality of included trials may limit the conclusions that indicate that modified SBS may have a promising treatment for improving FEV1/FVC and MVV, increasing exercise endurance and life quality scores on stable COPD patients. Pinoresinol diglucoside (PDG), the active compound extracted from Eucommia ulmoides, Styrax sp. and Forsythia suspensa, plays the roles in regulating hypertension, inflammation and oxidative stress. Considering that hypertension and inflammation has been proved to contribute to cardiac remodeling, we tested the effects of PDG on cardiac hypertrophy (CM). Male Sprague Dawley (SD) rats were used to construct hypertrophic rats by partial abdominal aortic constriction (AAC)-surgery. PDG solution (2mg/ml) was used to treat AAC-induced rats by intraperitoneal injection at low dose (L-PDG, 2.5mg/kg per day), medium dose (M-PDG, 5mg/kg per day), and high dose (H-PDG, 7.5mg/kg per day) for 3 weeks post AAC-surgery. CM was evaluated by the ratio of left ventricular weight to body weight ratio (LVW/BW), left ventricular wall thickness by H&E staining, and collagen content deposit by Masson's staining. Further, isoproterenol (ISO) and phenylephrine (PE) were used to produce cellular models of CM in neonatal ratin vivo and in vitro. PDG prevents AAC-induced CM in vivo, PE-