Multi-target, especially dual-target, drug design has become a popular research field for cancer treatment. Development of small molecule dual-target inhibitors through hybridization strategy can provide highly potent and selective anticancer agents. In this study, three series of quinazoline derivatives bearing a benzene-sulfonamide moiety were designed and synthesized as dual EGFR/CAIX inhibitors. All the synthesized compounds were evaluated against epidermoid carcinoma (A431) and non-small cell lung cancer (A549 and H1975) cell lines, which displayed weak to potent anticancer activity. In particular, compound 8v emerged as the most potent derivative against mutant-type H1975 cells, which exhibited comparable activity to osimertinib. Importantly, 8v exhibited stronger anti-proliferative activity than osimertinib against H1975 cells under hypoxic condition. Kinase inhibition studies indicated that 8v showed excellent inhibitory effect on EGFRT790M enzyme, which was 41 times more effective than gefitinib and almost equal to osimertinib. Mechanism studies revealed that 8v exhibited remarkable CAIX inhibitory effect comparable to acetazolamide and significantly inhibited the expression of p-EGFR as well as its downstream p-AKT and p-ERK in H1975 cells. Notably, 8v was found to inhibit the expression of CAIX and its upstream HIF-1α in H1975 cells under hypoxic condition. Molecular docking was also performed to gain insights into the ligand-binding interactions of 8v inside EGFRWT, EGFRT790M and CAIX binding sites.In situ TEM is a valuable technique to offer novel insights in the behavior of nanomaterials under various conditions. However, interpretation of in situ experiments is not straightforward since the electron beam can impact the outcome of such measurements. For example, ligands surrounding metal nanoparticles transform into a protective carbon layer upon electron beam irradiation and may impact the apparent thermal stability during in situ heating experiments. In this work, we explore the effect of different treatments typically proposed to remove such ligands. We found that plasma treatment prior to heating experiments for Au nanorods and nanostars increased the apparent thermal stability of the nanoparticles, while an activated carbon treatment resulted in a decrease of the observed thermal stability. Treatment with HCl barely changed the experimental outcome. These results demonstrate the importance of carefully selecting pre-treatments procedures during in situ heating experiments.Despite long-term practical experience with waste incineration plants, their operation under the conditions for which they were designed pose challenges, mainly due to the heterogeneous composition of the waste feed. Within the framework of the present paper, the operation of 6 waste incineration plants (five grate and one fluidized bed incinerator) have been analysed in terms of hourly steam production, waste throughput, auxiliary fuel consumption and air surplus over one year. The results reveal that the operation of the majority of the plants was negatively influenced during times of waste delivery. Reductions in steam production and waste throughput of up to 3% were observed for these times in comparison to periods without any delivery of waste. Furthermore, an increase in air surplus and auxiliary fuels consumption (up to a factor of 2) was noticed, both resulting in lower environmental performance. The results further indicate that incineration plants receiving their waste via trucks are more prone to impairments of performance than plants supplied via train delivery. This observation might be explained by the fact that train delivery requires a transfer of the waste from truck to train, which is typically associated with a mixing of the waste. Based on the observed impairment of the operation during waste delivery times, the related economic loss for plant operators is estimated to be several 100,000 Euros per year. Hence, in order to improve the performance of waste incineration plants, a better mixing of the waste, in particular during times of waste delivery, is recommended.This study quantifies and compares the cost of municipal solid waste (MSW) management systems under different scenarios using life cycle cost (LCC) analysis approach. LCC analysis was performed for six integrated MSW management scenarios for Mumbai city, India which generates over 9000 metric tonnes of MSW daily and disposes most of it in open dumps. The scenarios are the combinations of recycling, composting, anaerobic digestion, incineration with electricity generation, and landfill with biogas recovery. To perform LCC analysis of scenarios, present worth method was used. The present worth of operations and maintenance (O&M) cost and revenue generated was estimated using a discount rate of 11.25% for a 20-year life span. Results show that the incineration based scenario is the most cost-intensive option with a net LCC of US$38 per tonne of MSW due to the high capital cost involved in case of incineration. While the scenario with a combination of recycling and sanitary landfill was the most economically viable option with a net LCC of US$19 per tonne of MSW due to comparative lower operating cost.  https://www.selleckchem.com/products/GDC-0449.html  The sensitivity analysis shows that the O&M cost was the most sensitive parameter and a change of ±10% and ±20% in O&M cost, the net LCC of scenarios changes in the range of 14-33% and 29-65%, respectively. This study provides an economic comparison of MSW treatment scenarios from a life cycle perspective, which facilitates the decision-making process for improvement in cost estimation and planning of waste management strategies in India.Recycling of spent Li-ion batteries is crucial for achieving sustainable development of battery industry. Current recycling processes mainly focus on valuable metals but less attention has been paid to spent graphite, which generally ends up as secondary waste. In this study, a process for preparing graphene and recovering Li in anode as a by-product from spent graphite was developed. The key point was to re-charge the spent LIBs to generate lithium graphite intercalation compounds. The lithium graphite intercalation compounds were then subjected to a hydrolysis procedure and graphene could be produced through ultrasonic treatment via the expansion/micro-explosion mechanism. Experimental results demonstrated that 1-4 layered graphene could be efficiently produced when spent Li-ion batteries with beyond 50% capacity were re-charged. The prepared graphene showed high quantity containing few defects (ID/IG = 0.33, C/O = 13.2 by energy dispersive spectroscopy and C/O = 8.8 by X-ray photoelectron spectroscopy). In addition, Li was simultaneously recovered in the form of battery-grade lithium carbonate in the above process.